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General Information
Symbol
Dmel\EcRGD1428
Species
D. melanogaster
Name
FlyBase ID
FBal0206933
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-EcRRNAi, UAS-EcR RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ovaries from virgin females expressing EcRGD1428 under the control of Scer\GAL4C587 do not show changes in the number of germline stem cells in the germarium, as compared to controls.

The expression of EcRGD1428 under the control of Scer\GAL4r4 leads to lethality when individuals are reared under a high sugar diet (i.e. 1M sucrose), but not under a standard sugar diet (0.15M sucrose).

Expression of EcRGD1428 under the control of Scer\GAL4phm.PO leads to accumulation of lipid droplets in the prothoracic gland cells of third instar larvae.

Expression of EcRGD1428 under the control of Scer\GAL4Bx-MS1096 results in male flies with weak wing size and patterning defects.

Expression of EcRGD1428 under the control of Scer\GAL4Bx-MS1096 results in female flies with weak wing size and patterning defects.

Expression via Scer\GAL4ey-OK107 prevents proper differentiation of alpha/beta neurons in mushroom bodies, resulting in a smaller volume.

Expression via Scer\GAL4wor.PA and Scer\GAL80ase.PN prolongs the lifetime and prevents shrinkage of pupal neuroblasts (NBs). These longer lived NBs continue dividing for a longer time and generate more neuronal progeny than wild type.

Larvae expressing EcRGD1428 under the control of Scer\GAL4Hml.PG show normal rates of encapsulation of eggs when parasitised by the avirulent L. boulardi wasp strain G486.

Adults expressing EcRGD1428 under the control of the cardioblast-specific Scer\GAL4tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

Adults expressing EcRGD1428 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in early pupal lethality.

Downregulation of EcR through expression of EcRGD1428 in ddaC neurons under the control of Scer\GAL4109(2)80 causes strong ddaC pruning defects at 18h APF.

Expression under the control of Scer\GAL4pnr-MD237 results in lethality (either before or at the pupal stage), depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The G9aScer\UAS.cKa wing vein phenotype is almost completely suppressed by co-expression of EcRGD1428.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
EcRGD1428
Name Synonyms
Secondary FlyBase IDs
    References (24)