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General Information
Symbol
Dmel\EgfrGD1654
Species
D. melanogaster
Name
FlyBase ID
FBal0206949
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-EgfrRNAi, UAS-EGFR-RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Males expressing EgfrGD1654 under the control of Scer\GAL4Abd-B-LDN show normal genitalia rotation.

Adults expressing EgfrGD1654 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression of EgfrGD1654 under the control of Scer\GAL4elav-C155 results in flies with increased sensitivity to ethanol-induced sedation compared to control flies.

Expression of EgfrGD1654 under the control of Scer\GAL4GMR.PF results in a mild rough eye phenotype.

Expression under the control of Scer\GAL4pnr-MD237 results in a colour difference between the central Scer\GAL4pnr-MD237 expression domain of the notum and the surrounding lateral region in 30-40% or 80-90% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 10-20% or 20-30% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Enhanced by
Suppressor of
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The thickened wing vein phenotype of adults expressing anchorGD3613 under the control of Scer\GAL4A9 is not suppressed by addition of EgfrGD1654.

Border cell clusters in females co-expressing EgfrGD1654 and PvrGD2571 under the control of Scer\GAL4slbo.2.6 show a significantly reduced net cluster movement compared to wild type. There is a reduction in the number of cellular extensions from the front of the border cell cluster compared to wild type.

Expression of EgfrGD1654 under the control of Scer\GAL4elav-C155 significantly suppresses the sleep defects seen in homozygous rho-5KO1 mutants.

Compared with hpoBF33 mutant MARCM clones, hpoBF33 mutant clones expressing EgfrGD1654 exhibit reduced clone size. EgfrGD1654 expression suppresses the elevated levels of mitosis seen in hpoBF33 MARCM clones but not outside the expression domain of the MARCM clones.

The mild rough eye phenotype caused by expression of EgfrGD1654 under the control of Scer\GAL4GMR.PF is potently enhanced by co-expression of hppyRB.Scer\UAS.

The increased sensitivity to ethanol-induced sedation caused by expression of EgfrGD1654 under the control of Scer\GAL4elav-C155 is completely suppressed by either hppyKG05537 or hppy17-51.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
EgfrGD1654
Name Synonyms
Secondary FlyBase IDs
    References (17)