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General Information
Symbol
Dmel\DCTN1-p150GD1455
Species
D. melanogaster
Name
FlyBase ID
FBal0207114
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

DCTN1-p150 silencing in segmental nerves of L3 larvae (DCTN1-p150GD1455, Scer\GAL4D42) significantly reduces the rate of mitochondria transported in the retrograde direction, but has no effect on retrograde speed or anterograde speed/rate.

Scer\GAL4elav-C155-mediated co-expression of DCTN1-p150GD1455 has no apparent effect on eclosion rates.

Larvae expressing GlGD1455 under the control of Scer\GAL4Hml.PG show reduced encapsulation (10%) of eggs when parasitised by the avirulent L. boulardi wasp strain G486. Plasmatocytes fully cover the egg, while lamellocytes partially cover it.

Expression under the control of Scer\GAL41407 results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression of GlGD1455 under the control of Scer\GAL4upd results in a reduction in the number of outer border follicle cells compared to wild type and also results in defects in border follicle cell migration. Expression under the control of Scer\GAL4slbo.2.6 does not cause these phenotypes.

Adults expressing DCTN1-p150GD1455 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
NOT Enhancer of
NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Scer\GAL4elav-C155-mediated expression of Hsap\MAPTR406W.Scer\UAS in combination with silencing of DCTN1-p150 (DCTN1-p150GD1455) results in axonal swellings in larval segmental nerves.

Scer\GAL4elav-C155-mediated co-expression of Hsap\MAPTR406W.Scer\UAS with DCTN1-p150GD1455 strongly reduces eclosion rates.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
DCTN1-p150GD1455
GlGD1455
Name Synonyms
Secondary FlyBase IDs
    References (11)