Allele Dmel\Myd88^GD9716

General Information
Symbol	Dmel\Myd88^GD9716	Species	D. melanogaster
Name		FlyBase ID	FBal0207681
Feature type	allele	Associated gene	Dmel\Myd88

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dickson et al., 2007.7.18) in vitro construct - RNAi (Dickson et al., 2007.7.18)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :1..326
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Dickson et al., 2007.7.18)
Carried in construct	P{GD9716} (Dickson et al., 2007.7.18, Valanne et al., 2010, Mummery-Widmer et al., 2009)
Associated Sequence Features	dsRNA-GD9716
Cytology
Phenotypic Data
Phenotypic Class
	immune response defective, with Scer\GAL4^c564 (Valanne et al., 2010) viable, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009)
Phenotype Manifest In

Detailed Description
	Statement Reference Flies expressing Myd88[GD9716] under the control of Scer\GAL4[c564] show reduced survival compared to control flies when they are infected with M. luteus and then 24 hours later they are infected with E. faecalis. (Valanne et al., 2010)
External Data
Linkouts	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 9716
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference Myd88^GD9716, Scer\GAL4^Hml.Δ is a suppressor of sessile hemocyte phenotype of Scer\GAL4^Hml.Δ, Tl^10b.Scer\UAS (Valanne et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of Myd88[GD9716] suppresses the loss of the sessile hemocyte banding pattern which is seen in larvae expressing Tl[10b.Scer\UAS] under the control of Scer\GAL4[Hml.Δ]. (Valanne et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
VDRC	v25399 w¹¹¹⁸; P{GD9716}v25399 v25402 w¹¹¹⁸; P{GD9716}v25402
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts
	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 9716
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Myd88^GD9716 MyD88^IR (Sampson et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Sampson et al., 2012, Dev. Comp. Immunol. 38(1): 160--168 The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42. [FBrf0219019] Valanne et al., 2010, J. Immunol. 184(11): 6188--6198 Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. [FBrf0210846]
Supplementary material	Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

Allele Dmel\Myd88GD9716

Allele Dmel\Myd88^GD9716