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General Information
Symbol
Dmel\DroncGD12376
Species
D. melanogaster
Name
FlyBase ID
FBal0207720
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Dronc-RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of DroncGD12376 under the control of Scer\GAL4GMR.PF does not affect eye development.

Pruning of ddaC dendrites is delayed upon expression of NcGD12376 under the control of Scer\GAL4ppk.1.9. The degeneration of dendrites after severing is unaffected however.

Adults expressing DroncGD12376 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The co-expression of DroncGD12376 partially suppresses the severe decrease in size and the severe increase in apoptosis induced in the third instar larval wing disc posterior compartment by the expression of domeΔCYT.Scer\UAS under the control of Scer\GAL4en-e16E.

Co-expression of DroncGD12376 results in significant suppression of the increased apoptosis and increased proliferation of the mutant domain, preventing tumorigenesis in flies expressing Rab5GD10492 under the control of Scer\GAL4salm.EPv (in combination with a Gal80[ts] transgene to restrict expression to the third instar larval stage) in the wing pouch.

Expression of DroncGD12376 in the developing eye does not affect the eye roughness seen upon expression of AcnScer\UAS.cNa under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
DroncGD12376
NcGD12376
Name Synonyms
Secondary FlyBase IDs
    References (13)