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General Information
Symbol
Dmel\NmnatGD8082
Species
D. melanogaster
Name
FlyBase ID
FBal0207767
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing NmnatGD8082 under the control of Scer\GAL4tey-5053A (together with Dicer-2, for efficient RNAI) does not provide protection against (injury-induced) Wallerian degeneration of third instar larval motoneurons.

Sensory neuron clones in the adult wing expressing NmnatGD8082 under the control of Scer\GAL4VGlut-OK371 display axon and cell body degeneration.

Adults expressing NmnatGD8082 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in adult/pharate lethality.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

rawdcp-1 homozygotes show protection against (injury-induced) Wallerian degeneration of third instar larval motor, which is only very slightly suppressed by the expression of NmnatGD8082 under the control of Scer\GAL4tey-5053A (together with Dicer-2, for efficient RNAI).

The axon and cell body degeneration in sensory neuron clones in the adult wing expressing NmnatGD8082 under the control of Scer\GAL4VGlut-OK371 can be fully rescued by combination with axed0011, axed2094 or by axed2094 and Ect4896 together, partially so by combination with Ect4896 alone and is only marginally improved by hiwΔN.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
NmnatGD8082
Name Synonyms
Secondary FlyBase IDs
    References (7)