FlyBase Allele Report: Dmel\Rpt2[GD11600]

General Information

Symbol

Dmel\Rpt2^GD11600

Species

D. melanogaster

Name

FlyBase ID

FBal0208135

Feature type

allele

Associated gene

Dmel\Rpt2

Associated Insertion(s)

Carried in Construct

P{GD11600}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11600}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11600

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss

CEC

(Aharoni et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss

is ameliorated by Hsap\PSMC1^UAS.cAa

(Aharoni et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

interommatidial bristle | absent | adult stage, with Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

ommatidium | adult stage, with Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^Mef2.PR results in early pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality (either before or at the pupal stage), depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11600

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Rpt2^GD11600, Scer\GAL4^GMR.PU has abnormal eye color | adult stage phenotype, suppressible by Hsap\PSMC1^UAS.cAa, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Hsap\PSMC1^UAS.cAa, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Hsap\PSMC1^I255T.UAS, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has melanotic necrosis | adult stage phenotype, suppressible by Hsap\PSMC1^I255T.UAS, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has abnormal eye color | adult stage phenotype, suppressible by Hsap\PSMC1^I255T.UAS, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has melanotic necrosis | adult stage phenotype, suppressible by Hsap\PSMC1^UAS.cAa, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Phenotype Manifest In

Suppressed by

Statement

Reference

Rpt2^GD11600, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Hsap\PSMC1^UAS.cAa, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Hsap\PSMC1^I255T.UAS, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has interommatidial bristle | adult stage | absent phenotype, suppressible | partially by Hsap\PSMC1^UAS.cAa, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, suppressible | partially by Hsap\PSMC1^UAS.cAa, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

NOT suppressed by

Statement

Reference

Rpt2^GD11600, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, non-suppressible by Hsap\PSMC1^I255T.UAS, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Rpt2^GD11600, Scer\GAL4^GMR.PU has interommatidial bristle | adult stage | absent phenotype, non-suppressible by Hsap\PSMC1^I255T.UAS, Scer\GAL4^GMR.PU

(Aharoni et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v22052

w¹¹¹⁸; P{GD11600}v22052

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11600

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pros26.4^GD11600

Rpt2^GD11600

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections