FlyBase Allele Report: Dmel\Ptp10D[GD115]

General Information

Symbol

Dmel\Ptp10D^GD115

Species

D. melanogaster

Name

FlyBase ID

FBal0208157

Feature type

allele

Associated gene

Dmel\Ptp10D

Associated Insertion(s)

Carried in Construct

P{GD115}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD115}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD115

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cJa

(Jansen et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

partially lethal - majority die, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

Detailed Description

Statement

Reference

Expression of Ptp10D^GD115 under the control of Scer\GAL4^ninaE.PT does not induce retinal degeneration in adult flies.

(Jansen et al., 2017)

The expression of Ptp10D^GD115 under the control of Scer\GAL4^ppk.PG, in combination with Dicer-2 for efficient RNAi, results in a reduced dendritic arborization in third instar larval class IV abdominal dorsal multidendritic ddaC neurons, as compared to controls; expression under the control of Scer\GAL4²²¹, in combination with Dicer-2 for efficient RNAi, results in no obvious dendrite morphology defects in class I abdominal dorsal multidendritic ddaD and ddaE neurons, as compared to controls.

(Hattori et al., 2013)

Adults expressing Ptp10D^GD115 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in semi-lethality, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Ptp10D^GD115, Scer\GAL4^ninaE.PT is an enhancer of abnormal neuroanatomy | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

Ptp10D^GD115, Scer\GAL4^ninaE.PT is an enhancer of retina | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Ptp10D^GD115, Scer\GAL4^ninaE.PT is an enhancer of ommatidium | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The age-progressive retinal degeneration characteristic for flies expressing Hsap\SNCA^Scer\UAS.cJa under the control of Scer\GAL4^ninaE.PT is significantly enhanced by co-expression of Ptp10D^GD115.

(Jansen et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v1101

w¹¹¹⁸; P{GD115}v1101

v1102

w¹¹¹⁸; P{GD115}v1102

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ptp10D^GD115

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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