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General Information
Symbol
Dmel\RxGD4076
Species
D. melanogaster
Name
FlyBase ID
FBal0208431
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of an inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of RxGD4076 under the control of Scer\GAL4insc-Mz1407 results in a significant decrease in the number of mushroom body neuroblasts and Kenyon cells in the mushroom body at 72 h after puparium formation, a decrease in the number of mushroom body GMCs at the third instar stage, a reduction in proliferation of mushroom body neuroblasts and GMCs in late third instar brains, and a decrease in third instar mushroom body neuroblast and GMC size, as compared to controls.
Expression under the control of Scer\GAL41407 results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.
Adults expressing RxGD4076 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or late pupal lethality.
Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 10-20% or 30-40% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used. Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 30-40% or 90-100% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.
External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Co-expression of BacA\p35Scer\UAS.cHa restores the number of mushroom body neuroblasts, and partially restores the number of Kenyon cells to normal in flies expressing RxGD4076 under the control of Scer\GAL4insc-Mz1407 at 72 h APF.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
RxGD4076
Name Synonyms
Secondary FlyBase IDs
    References (7)