UASt regulatory sequences drive expression of an inverted repeat.
Expression of Src64BGD12263 under the control of Scer\GAL4GMR.PF at 29[o]C results in male eyes that are 42% smaller than controls.
Adults expressing Src64BGD12263 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Scer\GAL4da.PU/Src64BGD12263, Scer\GAL80ts.αTub84B is a non-enhancer of lethal - all die during pupal stage | heat sensitive phenotype of Scer\GAL4da.PU, Scer\GAL80ts.αTub84B, fzrRNAi.UAS.WIZ
Scer\GAL4FRT.Act5C/Src64BGD12263 is a suppressor of lethal - all die during larval stage phenotype of Scer\GAL4FRT.Act5C, l(2)gl4
Src64BGD12263, Scer\GAL4FRT.Act5C is a suppressor of lethal - all die during larval stage phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C
Src64BGD12263, Scer\GAL4FRT.Act5C is a suppressor of increased cell growth rate phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C, l(2)gl4
Src64BGD12263, Scer\GAL4FRT.Act5C is a suppressor of abnormal neuroanatomy phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C, l(2)gl4
Src64BGD12263, Scer\GAL4FRT.Act5C is a suppressor of neoplasia phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C, l(2)gl4
Src64BGD12263, Scer\GAL4GMR.PF is a suppressor | partially of visible | adult stage phenotype of HAdV-C\E4orf4UAS.cPa, Scer\GAL4GMR.PF
Src64BGD12263, Scer\GAL4GMR.PF is a suppressor | partially of abnormal size | adult stage phenotype of HAdV-C\E4orf4UAS.cPa, Scer\GAL4GMR.PF
Scer\GAL4da.PU/Src64BGD12263, Scer\GAL80ts.αTub84B is a non-suppressor of lethal - all die during pupal stage | heat sensitive phenotype of Scer\GAL4da.PU, Scer\GAL80ts.αTub84B, fzrRNAi.UAS.WIZ
Src64BGD12263, Scer\GAL4NP7397 is a non-suppressor of increased occurrence of cell division | adult stage phenotype of RetUAS.Tag:FLAG,Tag:polyHis, Scer\GAL4NP7397
Scer\GAL4NP7397, Src42AGD10610, Src64BGD12263 has abnormal immune response | adult stage phenotype
Scer\GAL4NP7397, Src42AGD10610, Src64BGD12263 has decreased cell number | adult stage phenotype
Scer\GAL4NP7397, Src42AGD10610, Src64BGD12263 has decreased occurrence of cell division | adult stage | conditional phenotype
Src64BGD12263, Scer\GAL4FRT.Act5C is a suppressor of larval ventral nerve cord phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C, l(2)gl4
Src64BGD12263, Scer\GAL4GMR.PF is a suppressor | partially of eye phenotype of HAdV-C\E4orf4UAS.cPa, Scer\GAL4GMR.PF
Src64BGD12263, Scer\GAL4NP7397 is a non-suppressor of intestinal stem cell of posterior adult midgut epithelium phenotype of RetUAS.Tag:FLAG,Tag:polyHis, Scer\GAL4NP7397
Scer\GAL4NP7397, Src42AGD10610, Src64BGD12263 has adult midgut phenotype
The increased number of intestinal progenitor cells in mitosis characteristic for adult flies expressing RetScer\UAS.T:Zzzz\FLAG,T:Zzzz\His6 driven by Scer\GAL4esg-NP7397 (combined with tub-Gal80[ts] for temporal control) is not suppressed by co-expression of Src64BGD12263.
Loss of Src64B, through expression of Src64BGD12263, dramatically suppresses tumour cell invasion into the ventral nerve cord in Ras85DV12.Scer\UAS/l(2)gl4 mutants and enables the animals to survive to the pupal stage, whereas the tumour size remains largely unaffected.
Expression of Src64BGD12263 partially suppresses the eye phenotypes seen in males when Zzzz\E4orf4Scer\UAS.cPa is expressed under the control of Scer\GAL4GMR.PF at 29[o]C. Eye size is restored to 63% of controls.