Allele Dmel\Su(var)205^GD12524

General Information
Symbol	Dmel\Su(var)205^GD12524	Species	D. melanogaster
Name		FlyBase ID	FBal0208654
Feature type	allele	Associated gene	Dmel\Su(var)205

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dickson et al., 2007.7.18) in vitro construct - RNAi (Dickson et al., 2007.7.18)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :139..331 :18..138 :1..17
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Dickson et al., 2007.7.18)
Carried in construct	P{GD12524} (Dickson et al., 2007.7.18, Wang and Elgin, 2011, Font-Burgada et al., 2008, Neumüller et al., 2011, Mummery-Widmer et al., 2009)
Associated Sequence Features	dsRNA-GD12524
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Neumüller et al., 2011) neuroanatomy defective \| larval stage (Neumüller et al., 2011) viable, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009)
Phenotype Manifest In
	embryonic/larval neuroblast \| larval stage (Neumüller et al., 2011) ganglion mother cell \| larval stage (Neumüller et al., 2011)
Detailed Description
	Statement Reference Expression under the control of Scer\GAL4[1407] results in loss of neuroblasts in the larval brain associated with increased size of the remaining neuroblasts. Expression under the control of Scer\GAL4[1407] results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls. Expression under the control of Scer\GAL4[1407] may result in mild defects in the shape of ganglion mother cells in the larval brain (depending on the insertion line used). Expression under the control of Scer\GAL4[1407] results in mild defects in the shape of neuroblasts in the larval brain. (Neumüller et al., 2011) Expression under the control of Scer\GAL4[pnr-MD237] results in loss of bristles on the notum in 0% or 10-20% of the Scer\GAL4[pnr-MD237] expression domain, depending on the insertion line used. Expression under the control of Scer\GAL4[pnr-MD237] results in planar polarity defects in the orientation of bristles of the notum in 0% or 20-30% of the Scer\GAL4[pnr-MD237] expression domain, depending on the insertion line used. (Mummery-Widmer et al., 2009)
External Data
Linkouts	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 12524 Neuroblasts Screen Database - A database for RNAi phenotypes in larval neural stem cells • 12524
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
VDRC	v31994 w¹¹¹⁸; P{GD12524}v31994 v31995 w¹¹¹⁸; P{GD12524}v31995
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts
	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 12524 Neuroblasts Screen Database - A database for RNAi phenotypes in larval neural stem cells • 12524
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	hp1a^RNAi (Font-Burgada et al., 2008) Su(var)205^GD12524
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Wang and Elgin, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(52): 21164--21169 Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line. [FBrf0217081] Font-Burgada et al., 2008, Genes Dev. 22(21): 3007--3023 Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression. [FBrf0206169]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

Allele Dmel\Su(var)205GD12524

Allele Dmel\Su(var)205^GD12524