FlyBase Allele Report: Dmel\Syx7[GD2767]

General Information

Symbol

Dmel\Syx7^GD2767

Species

D. melanogaster

Name

FlyBase ID

FBal0208684

Feature type

allele

Associated gene

Dmel\Syx7

Associated Insertion(s)

Carried in Construct

P{GD2767}

Also Known As

avl-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2767}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2767

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Santabárbara-Ruiz and Léopold, 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cancer

is exacerbated by Oatp33Eb^UAS.cSa

(Santabárbara-Ruiz and Léopold, 2021)

is exacerbated by Oatp74D^UAS.cOa

(Santabárbara-Ruiz and Léopold, 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

imaginal disc, with Scer\GAL4^rn-GAL4-5

(Colombani et al., 2012)

wing disc, with Scer\GAL4^rn-GAL4-5

(Andersen et al., 2015)

Detailed Description

Statement

Reference

Scer\GAL4^rn-GAL4-5-mediated expression results in neoplastic wing disc overgrowth.

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5-mediated expression of Syx7^GD2767 induces a robust delay in the larva-to-pupa transition of about 2-3 days. Discs reach near-normal size after 5 days of development, then undergo unrestricted neoplastic growth. Animals grow at the same rate as controls but fail to pupariate at the normal time, giving rise to giant larvae and pupae after 2-3 days of extra growth.

(Colombani et al., 2012)

Adults expressing Syx7^GD2767 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in late pupal lethality or undefined lethality.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2767

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, suppressible by grnd^GD12580/Scer\GAL4^rn-GAL4-5

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, suppressible by Scer\GAL4^rn-GAL4-5/ben^KK101929

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, suppressible by Tab2^KK105926/Scer\GAL4^rn-GAL4-5

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, suppressible by Scer\GAL4^rn-GAL4-5/Tak1^KK108611

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, suppressible by hep^KK116295/Scer\GAL4^rn-GAL4-5

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, suppressible by bsk^KK108156/Scer\GAL4^rn-GAL4-5

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, suppressible by grnd^KK109939/Scer\GAL4^rn-GAL4-5

(Andersen et al., 2015)

NOT suppressed by

Statement

Reference

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, non-suppressible by egr¹/egr³

(Andersen et al., 2015)

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has neoplasia phenotype, non-suppressible by Ilp8^KK112161, Scer\GAL4^rn-GAL4-5

(Colombani et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has phenotype, suppressible by Ilp8^KK112161, Scer\GAL4^rn-GAL4-5

(Colombani et al., 2012)

Scer\GAL4^rn-GAL4-5, Syx7^GD2767 has phenotype, suppressible by puc^UAS.cMa/Scer\GAL4^rn-GAL4-5

(Colombani et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of Ilp8^KK112161 rescues the delay at pupariation of Scer\GAL4^rn-GAL4-5, Syx7^GD2767 animals, but does not suppress their overgrowth phenotype.

Coexpression of puc^Scer\UAS.cMa rescues the delay at pupariation of Scer\GAL4^rn-GAL4-5, Syx7^GD2767 animals.

(Colombani et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v5413

w¹¹¹⁸; P{GD2767}v5413

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2767

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Syx7^GD2767

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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