Open Close
General Information
Symbol
Dmel\Syx7GD2767
Species
D. melanogaster
Name
FlyBase ID
FBal0208684
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
avl-RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Scer\GAL4rn-GAL4-5-mediated expression results in neoplastic wing disc overgrowth.

Scer\GAL4rn-GAL4-5-mediated expression of Syx7GD2767 induces a robust delay in the larva-to-pupa transition of about 2-3 days. Discs reach near-normal size after 5 days of development, then undergo unrestricted neoplastic growth. Animals grow at the same rate as controls but fail to pupariate at the normal time, giving rise to giant larvae and pupae after 2-3 days of extra growth.

Adults expressing Syx7GD2767 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in late pupal lethality or undefined lethality.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Coexpression of Ilp8KK112161 rescues the delay at pupariation of Scer\GAL4rn-GAL4-5, Syx7GD2767 animals, but does not suppress their overgrowth phenotype.

Coexpression of pucScer\UAS.cMa rescues the delay at pupariation of Scer\GAL4rn-GAL4-5, Syx7GD2767 animals.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Syx7GD2767
Name Synonyms
Secondary FlyBase IDs
    References (9)