FlyBase Allele Report: Dmel\Tace[GD572]

General Information

Symbol

Dmel\Tace^GD572

Species

D. melanogaster

Name

FlyBase ID

FBal0208704

Feature type

allele

Associated gene

Dmel\Tace

Associated Insertion(s)

Carried in Construct

P{GD572}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Chabu and Xu, 2014, Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD572}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD572

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PFa

(Muliyil et al., 2020)

abnormal neuroanatomy | adult stage, with Scer\GAL4^sv.PJ

(Muliyil et al., 2020)

decreased cell number | adult stage, with Scer\GAL4^GMR.PFa

(Muliyil et al., 2020)

decreased cell number | adult stage, with Scer\GAL4^sv.PJ

(Muliyil et al., 2020)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

eye photoreceptor cell | decreased number, with Scer\GAL4^GMR.PFa

(Muliyil et al., 2020)

eye photoreceptor cell | decreased number, with Scer\GAL4^sv.PJ

(Muliyil et al., 2020)

lipid droplet | adult stage | increased number, with Scer\GAL4^Act5C.PI

(Muliyil et al., 2020)

lipid droplet | adult stage | increased number, with Scer\GAL4^sv.PJ

(Muliyil et al., 2020)

pigment cell | decreased number, with Scer\GAL4^GMR.PFa

(Muliyil et al., 2020)

retina, with Scer\GAL4^GMR.PFa

(Muliyil et al., 2020)

retina, with Scer\GAL4^sv.PJ

(Muliyil et al., 2020)

Detailed Description

Statement

Reference

Expression of Tace^GD572 under the control of Scer\GAL4^GMR.PFa leads to degeneration of both photoreceptor cells and the surrounding pigmented glial cells (pigment cells) and its expression under the control of Scer\GAL4^sv.PJ leads to retinal degeneration in 5-week-old flies when compared to controls.

Expression of Tace^GD572 under the control of Scer\GAL4^Act5C.PI or Scer\GAL4^sv.PJ leads to accumulation of lipid droplets in retinas of 1-day-old flies when compared to controls.

(Muliyil et al., 2020)

Eye-antennal disc clones expressing Tace^GD572 under the control of Scer\GAL4^Act.PU do not show overgrowth compared with controls.

(Chabu and Xu, 2014)

Adults expressing Tace^GD572 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Tace^GD572/Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Scer\GAL4^GMR.PU, bsk^DN.UAS, egr^UAS.cIa

(Chabu and Xu, 2014)

Suppressor of

Statement

Reference

Tace^GD572/Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Chabu and Xu, 2014)

Tace^GD572, Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Other

Statement

Reference

Scer\GAL4^GMR.PU, Tace^GD572, bsk^DN.UAS, egr^UAS.cIa has increased cell death phenotype

(Chabu and Xu, 2014)

Scer\GAL4^GMR.PU, Tace^GD572, bsk^DN.UAS, egr^UAS.cIa has majority die during pupal stage phenotype

(Chabu and Xu, 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Tace^GD572/Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, bsk^DN.UAS, egr^UAS.cIa

(Chabu and Xu, 2014)

Suppressor of

Statement

Reference

Tace^GD572/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Chabu and Xu, 2014)

Tace^GD572, Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Tace^GD572 suppresses the small eye phenotype seen when egr^Scer\UAS.cIa is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Tace^GD572 enhances the hanging eye phenotype seen when egr^Scer\UAS.cIa and bsk^DN.Scer\UAS are co-expressed under the control of Scer\GAL4^GMR.PU. The majority of these triple mutant animals die in late pupal stages and show a ring of necrotic tissue around the eyes.

Expression of Tace^GD572 suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The phenotype is further suppressed when the adjacent cells are homozygous mutant for Tak1¹.

(Chabu and Xu, 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v2733

w¹¹¹⁸; P{GD572}v2733

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tace^GD572

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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