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General Information
Symbol
Dmel\Tap42GD8900
Species
D. melanogaster
Name
FlyBase ID
FBal0208738
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Tap42GD8900 under the control of Scer\GAL4Act5C.PI causes complete lethality.

Expression of Tap42GD8900 under the control of Scer\GAL4GMR.long does not lead to any apparent defect in the compound eye.

Expression of Tap42GD8900 under the control of Scer\GAL4dpp.blk1 does not lead to any apparent phenotype.

Expression of Tap42GD8900 under the control of Scer\GAL4pnr-MD237 results in reduced survival rate to adulthood, and survivors display a marked thorax cleft, but no wing defects, as compared to controls.

Expression of Tap42GD8900 under the control of Scer\GAL4ap-md544 results in reduced survival rate to adulthood, and survivors display varying degrees of a cleft thorax, completely shrivelled wings, and a subset of these flies display necrosis of the front leg joints, as compared to controls. The wing discs of flies expressing Tap42GD8900 under the control of Scer\GAL4ap-md544 show arrest of cell proliferation in the notum region, but no obvious changes in cell proliferation in the wing compartment; and also show increased apoptosis in the wing blade region, as compared to control wing discs.

Expression under the control of Scer\GAL41407 results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control of Scer\GAL41407 results in extreme defects in the shape of ganglion mother cells in the larval brain.

Expression under the control of Scer\GAL41407 results in extreme defects in the shape of neuroblasts in the larval brain.

Expression under the control of Scer\GAL4Mef2.PR results in late pupal lethality.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of bskDN.Scer\UAS.cUa fails to rescue the cleft thorax phenotype of flies expressing Tap42GD8900 under the control of Scer\GAL4ap-md544.

mtsXE-2258/+ partially rescues the cleft thorax and wing phenotypes, and rescues survival of flies expressing Tap42GD8900 under the control of Scer\GAL4ap-md544.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Co-expression of Tap42Scer\UAS.cCa, but not Tap42ED.Scer\UAS, rescues the thorax and wing development phenotypes of flies expressing Tap42GD8900 under the control of Scer\GAL4ap-md544.

Co-expression of Tap42Scer\UAS.cCa, but not Tap42ED.Scer\UAS, rescues the thorax defect and reduced survival of flies expressing Tap42GD8900 under the control of Scer\GAL4pnr-MD237.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Tap42GD8900
Name Synonyms
Secondary FlyBase IDs
    References (5)