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General Information
Symbol
Dmel\mrnGD4089
Species
D. melanogaster
Name
FlyBase ID
FBal0208772
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of mrnGD4089 under the control of Scer\GAL4Bx-MS1096 results in wings which are smaller than normal, have a "bent-out" shape and which contain extra wing veins. Wing cell size is smaller than normal, and the total number of cells in the wing is reduced compared to wild type. BrdU incorporation is normal in wing discs expressing mrnGD4089 under the control of Scer\GAL4Bx-MS1096, but the number of apoptotic cells is increased compared to controls.

Expression of mrnGD4089 under the control of Scer\GAL4en.PU results in wings which are smaller than normal, have a highly reduced posterior crossvein, and contain extra wing veins (which can be formed outside the domain of Scer\GAL4en.PU expression).

Adults expressing mrnGD4089 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in a weak flyer phenotype.

Expression under the control of Scer\GAL4pnr-MD237 results in lethality or semi-lethality at the pupal stage, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 60-70% of the Scer\GAL4pnr-MD237-expressing area of the notum.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of p53Ct.GUS enhances the wing defects seen in flies expressing mrnGD4089 under the control of Scer\GAL4Bx-MS1096.

Co-expression of p53Ct.GUS enhances the increased apoptosis seen in the wing discs of animals expressing mrnGD4089 under the control of Scer\GAL4Bx-MS1096.

The massive apoptosis seen in wing discs co-expressing p53Ct.GUS and mrnGD4089 under the control of Scer\GAL4Bx-MS1096 is practically abolished by co-expression of bskGD10555.

Xenogenetic Interactions
Statement
Reference

Co-expression of mrnGD4089 and BacA\p35Scer\UAS.cUa under the control of Scer\GAL4Bx-MS1096 results in wings containing a large blister.

Co-expression of BacA\p35Scer\UAS.cUa suppresses the increased number of apoptotic cells seen in the wing discs of animals expressing mrnGD4089 under the control of Scer\GAL4Bx-MS1096.

The massive apoptosis seen in wing discs co-expressing p53Ct.GUS and mrnGD4089 under the control of Scer\GAL4Bx-MS1096 is suppressed by co-expression of BacA\p35Scer\UAS.cUa.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Tfb2GD4089
mrnGD4089
Name Synonyms
Secondary FlyBase IDs
    References (6)