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General Information
Symbol
Dmel\Traf6GD7146
Species
D. melanogaster
Name
FlyBase ID
FBal0208835
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-TRAF2-RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing Traf6GD7146 under the control of Scer\GAL4C587 (together with Dicer-2, for a more efficient RNAi) does not induce any major L3 spermatogenesis defects.

Adults expressing Traf6GD7146 under the control of Scer\GAL4NP0001 do not exhibit significant mortality to Ecc15 enteric infection, as compared to controls.

Expression of Traf6GD7146 under the control of either Scer\GAL4esg-NP5130 or Scer\GAL4Myo31DF-NP0001 results in impaired intestinal stem cell proliferation in response to paraquat.

Adults expressing Traf6GD7146 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or early pupal lethality.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Traf6GD7146 under the control of Scer\GAL4Act5C.PU suppresses the resistance to paraquat seen in pucB48/+ mutant flies. Mortality rates are increased compared to controls.

Expression of Traf6GD7146 suppresses the rough eye phenotype and third instar larval eye disc cell death seen when Atg9Scer\UAS.T:Zzzz\FLAG is expressed under the control of Scer\GAL4GMR.PU.

Xenogenetic Interactions
Statement
Reference

Co-expression of Traf6GD7146 partially suppresses the wing defects caused by expression of HIV-1\VpuScer\UAS.cLa under the control of Scer\GAL4dpp.blk1.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Traf2GD7146
Traf6GD7146
Name Synonyms
Secondary FlyBase IDs
    References (12)