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General Information
Symbol
Dmel\UchGD11265
Species
D. melanogaster
Name
FlyBase ID
FBal0208915
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dUCH-IR
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of an inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The expression of UchGD11265 under the control of Scer\GAL4ple.PF results in locomotor dysfunction and deficit in both larvae and adults, loss of larval DL1 cluster DA neurons, but not DM1a, DM1b, DM2, DL2a or DL2b cluster DA neurons, and loss of adult PPM2, PPM3 (only from the PPM3b sub-cluster), PPL2ab and VUM cluster DA neurons, as compared to controls. The expression of UchGD11265 also results in pupal lethality (driven by Scer\GAL4Act5C.PI), in a rough eye phenotype (driven by Scer\GAL4GMR.PS), in an abnormal vein pattern (driven by Scer\GAL4Bx-MS1096), in abnormal bristle and hair patterns (driven by Scer\GAL4pnr-MD237), in a progressive locomotor deficit (driven by Scer\GAL4Ddc.PL), and in an abnormal morphology larval neuromuscular junction morphology, namely longer branches and fewer and bigger type Ib boutons (driven by Scer\GAL4Toll-6-D42), as compared to controls.
No phenotype is observed when UchGD11265 is expressed using Scer\GAL4sqh.PW or Scer\GAL4elav.PU.
Adults expressing UchGD11265 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
UchGD11265
Name Synonyms
Secondary FlyBase IDs
    References (10)