FlyBase Allele Report: Dmel\aPKC[GD1366]

General Information

Symbol

Dmel\aPKC^GD1366

Species

D. melanogaster

Name

FlyBase ID

FBal0209037

Feature type

allele

Associated gene

Dmel\aPKC

Associated Insertion(s)

Carried in Construct

P{GD1366}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1366}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1366

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1366

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

aPKC^GD1366/Scer\GAL4^da.PU, Scer\GAL80^ts.αTub84B is a non-enhancer of lethal - all die during pupal stage | heat sensitive phenotype of Scer\GAL4^da.PU, Scer\GAL80^ts.αTub84B, fzr^RNAi.UAS.WIZ

(Neuert et al., 2017)

Suppressor of

Statement

Reference

aPKC^GD1366/Scer\GAL4^insc-Mz1407 is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Pfdn2^Δ10/Pfdn2⁰¹²³⁹

(Zhang et al., 2016)

aPKC^GD1366/Scer\GAL4^insc-Mz1407 is a suppressor | partially of increased cell number | third instar larval stage phenotype of Pfdn2^Δ10/Pfdn2⁰¹²³⁹

(Zhang et al., 2016)

NOT Suppressor of

Statement

Reference

aPKC^GD1366/Scer\GAL4^da.PU, Scer\GAL80^ts.αTub84B is a non-suppressor of lethal - all die during pupal stage | heat sensitive phenotype of Scer\GAL4^da.PU, Scer\GAL80^ts.αTub84B, fzr^RNAi.UAS.WIZ

(Neuert et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

aPKC^GD1366/Scer\GAL4^insc-Mz1407 is a suppressor | partially of neuroblast | increased number | third instar larval stage phenotype of Pfdn2^Δ10/Pfdn2⁰¹²³⁹

(Zhang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The dramatically increased average number of brain neuroblasts characteristic for Pfdn2^Δ10/Pfdn2⁰¹²³⁹ transheterozygote third instar larvae is partially restored by expression of aPKC^GD1366 under the control of Scer\GAL4^insc-Mz1407 in the mutant background.

(Zhang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v2907

w¹¹¹⁸; P{GD1366}v2907/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1366

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

aPKC^GD1366

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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