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General Information
Symbol
Dmel\benGD1387
Species
D. melanogaster
Name
FlyBase ID
FBal0209139
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-ben-IR
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Expression of benGD1387 ameliorates tumor-like growth and invasion when Ras85DV12.Scer\UAS is expressed in l(2)gl4 mutant cells.

Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Down-regulation of ben, through expression of benGD1387 under the control of Scer\GAL4Mhc.PW results in no change in overall muscular mitochondria morphology in the thorax.

Down-regulation of ben, through expression of benGD1387 under the control of Scer\GAL4Mhc.PW does not affect mitochondrial ATP production.

Adults expressing benGD1387 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in lethality by 7 days after eclosion.

Expression under the control of Scer\GAL4pnr-MD237 results in extra bristles on the notum in 50-60% of the Scer\GAL4pnr-MD237 expression domain.

Expression under the control of Scer\GAL4pnr-MD237 results in mild thorax closure defects.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
NOT Enhancer of
Suppressor of
NOT Suppressor of
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of benGD1387 strongly suppresses the small eye phenotype seen in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PU. This suppression is partially reverted upon expression of either ben+t6, benEP1651 or bend09936.

Expression of benGD1387 strongly suppresses the scutellum phenotype seen when egrScer\UAS.cIa is expressed under the control of Scer\GAL4pnr.PU.

Expression of benGD1387 significantly suppresses the growth and invasion of the tumors seen when Ras85DV12.Scer\UAS is expressed in l(2)gl4 mutant cells in eye-antennal discs using the ey-FLP/MARCM system.

Expression of benGD1387 suppresses the cell migration seen when scribGD11666 is expressed along the anterior/posterior (A/P) compartment boundary of wing imaginal discs under the control of Scer\GAL4ptc.PU.

Loss of ben, through expression of benGD1387, significantly suppresses the Scer\GAL4GMR.PF->nopoScer\UAS.cUa small rough eye phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
benGD1387
Name Synonyms
Secondary FlyBase IDs
    References (11)