The wing undergrowth observed in flies expressing either exScer\UAS.P\T.T:Avic\GFP-EGFP or kibraScer\UAS.P\T.cYa under the control of Scer\GAL4nub-AC-62 (their wing area is significantly decreased compared to controls) is modified by co-expression of crbGD14463 (which on its own leads to wing overgrowth), but whereas the small wing size of exScer\UAS.P\T.T:Avic\GFP-EGFP-expressing flies is increased, in the case of kibraScer\UAS.P\T.cYa, the wing size is further reduced by co-expression of crbGD14463.
Expression of crbGD14463 under the control of Scer\GAL4btl.PS partially suppresses the tracheal morphogenesis defects seen in GckIIIwheezy-770 mutant third instar larvae. Transition zone dilation is completely suppressed in 61% of terminal cells and partially suppressed in a further 27%.
Co-expression of crbGD14463 significantly rescues the eye neurodegeneration phenotype caused by expression of Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU. The increased cell death phenotype which is seen in the eye imaginal discs of animals expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU is also significantly suppressed.