Allele Dmel\d^GD4041

General Information
Symbol	Dmel\d^GD4041	Species	D. melanogaster
Name		FlyBase ID	FBal0209322
Feature type	allele	Associated gene	Dmel\d

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dickson et al., 2007.7.18) in vitro construct - RNAi (Dickson et al., 2007.7.18)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :1..337
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Dickson et al., 2007.7.18)
Carried in construct	P{GD4041} (Dickson et al., 2007.7.18, Petzoldt et al., 2012, Yue et al., 2012, Rauskolb et al., 2011, Mummery-Widmer et al., 2009, Bosveld et al., 2012, Bosveld et al., 2012)
Associated Sequence Features	dsRNA-GD4041
Cytology
Phenotypic Data
Phenotypic Class
	planar polarity defective, with Scer\GAL4^unspecified (Bosveld et al., 2012) viable, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009) visible, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009)
Phenotype Manifest In
	mesothoracic tergum, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009) scutellum, with Scer\GAL4^unspecified (Bosveld et al., 2012) trichogen cell, with Scer\GAL4^pnr-MD237 (Mummery-Widmer et al., 2009)
Detailed Description
	Statement Reference Significant differences in local cell contraction rates are observed between wild-type and d[GD4041]-expressing tissues within the region displaying polarised d expression in the future scutellum. The orientation of significant differences are aligned with the local orientations of d anisotropy distribution. The differences in contraction rates between wild-type and d[GD4041]-expressing tissues is mainly associated with a decrease in the contribution of cell rearrangements to tissue contractions in the region of d polarisation and, to a lesser extent, to cell shape changes. Pupae expressing d[GD4041] under the control of Scer\GAL4[unspecified] manifest defects in the shape of the adult scutellum. (Bosveld et al., 2012) Flies expressing d[GD4041] under the control of either Scer\GAL4[Abd-B-LDN] or Scer\GAL4[tsh-md621] show normal rotation of the male genitalia. (Petzoldt et al., 2012) Expression under the control of Scer\GAL4[pnr-MD237] results in bristle morphology defects on the notum in 0% or 50-60% of the Scer\GAL4[pnr-MD237] expression domain, depending on the insertion line used. Expression under the control of Scer\GAL4[pnr-MD237] results in the absence of 0% or 40-50% of the Scer\GAL4[pnr-MD237]-expressing area of the notum, depending on the insertion line used. Expression under the control of Scer\GAL4[pnr-MD237] may result in mild thorax closure defects, depending on the insertion line used. (Mummery-Widmer et al., 2009)
External Data
Linkouts	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 4041
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
VDRC	v12555 w¹¹¹⁸; P{GD4041}v12555 v12556 w¹¹¹⁸; P{GD4041}v12556/TM3
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts
	Bristle Screen Database - A database for RNAi phenotypes in bristle and notum development • 4041
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	d^GD4041
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Bosveld et al., 2012, Science 336(6082): 724--727 Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway. [FBrf0218281] Petzoldt et al., 2012, Development 139(10): 1874--1884 DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment. [FBrf0218056] Yue et al., 2012, Dev. Cell 22(2): 255--267 The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the hippo signaling pathway. [FBrf0217474] Rauskolb et al., 2011, PLoS Biol. 9(6): e1000624 Zyxin links fat signaling to the hippo pathway. [FBrf0213900]
Supplementary material	Bosveld et al., 2012, Science 336(6082): Supporting Online Material (SOM): Materials and methods. [FBrf0218770] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

Allele Dmel\dGD4041

Allele Dmel\d^GD4041