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General Information
Symbol
Dmel\DecayGD8484
Species
D. melanogaster
Name
FlyBase ID
FBal0209339
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of DecayGD8484 under the control of Scer\GAL4ap-md544, with or without Dicer-2 expression (for a more efficient RNAI) leads to curly but not opaque wings, which indicates growth inhibition during development without apoptosis.

Expression under the control of Scer\GAL4C10 leads to a significant decrease in wing size, as compared to controls. Wing discs do not show changes in apoptosis (assessed by PARP:VENUS signal and TUNEL assay), as compared to controls.

Adults expressing DecayGD8484 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Pupae expressing decayGD8484 under the control of Scer\GAL4NP1 undergo midgut histolysis at a similar rate as wild-type animals.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 0% or 10-20% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Pupae expressing decayGD8484 under the control of Scer\GAL4NP1 in a IceΔ1 Ncunspecified background undergo midgut histolysis at a similar rate as wild-type animals.

The delayed midgut histolysis phenotype seen in animals expressing Atg18GD12342 under the control of Scer\GAL4NP1 after puparium formation is not enhanced by co-expression of decayGD8484.

The delayed midgut histolysis phenotype seen in animals expressing Atg1GD7149 under the control of Scer\GAL4NP1 after puparium formation is not enhanced by co-expression of decayGD8484.

Xenogenetic Interactions
Statement
Reference

Pupae co-expressing decayGD8484 and BacA\p35Scer\UAS.cHa under the control of Scer\GAL4NP1 undergo midgut histolysis at a similar rate as wild-type animals.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
DecayGD8484
decayGD8484
Name Synonyms
Secondary FlyBase IDs
    References (7)