FlyBase Allele Report: Dmel\Myc[GD1419]

Expression of Myc^GD1419 under the control of Scer\GAL4^repo.PU leads to a decrease in the brain volume, glial cell size and glial nucleolus size in third instar larvae.

(Shohayeb et al., 2020)

Expressing Myc^GD1419 under the control of Scer\GAL4^ptc-559.1 results in small, underdeveloped larval salivary glands, as compared to controls; there is a severe decrease in DNA content.

(Yanku et al., 2018)

Scer\GAL4^Cg.PA Myc^GD1419 animals reach pupation with a delay of 48h at their third instar transition; these animals are smaller throughout development, and eclose 2 days later than controls as smaller, lighter adults. Scer\GAL4^Cg.PA Myc^GD1419 flies have small wings, owing to decreased size and number of cells. Scer\GAL4^Cg.PA Myc^GD1419 flies also have eyes with smaller and fewer ommatidia. Scer\GAL4^ppl.PU Myc^GD1419 flies have smaller wings comprising smaller cells.

Scer\GAL4^Hml.PG-mediated expression of Myc^GD1419 does not affect developmental timing or body/wing size.

Fat cells in the fat bodies of Scer\GAL4^Cg.PA Myc^GD1419 animals contain cytoplasmic lipid droplets larger in size than controls. The fat cells are smaller and contain less triglyceride compared to controls.

The half-life of Scer\GAL4^Cg.PA Myc^GD1419 animals during starvation is decreased compared to controls.

(Parisi et al., 2013)

Over-expression of dm^GD1419 using Scer\GAL4^sca-109-68 decreases the nuclear and nucleolar size of the posterior scutellar shaft cells.

(Kawamori and Yamaguchi, 2011)

Adults expressing Myc^GD1419 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing Myc^GD1419 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in early pupal lethality or late larval lethality.

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

(Schnorrer et al., 2010)

Mosaic clones expressing dm^GD1419 under the control of Scer\GAL4^αTub84B.PP exhibit a reduced number of cells with respect to those observed in wild-type clones.

(Ziosi et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality (either before or at the pupal stage), depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1419

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Myc^GD1419, Scer\GAL4^repo.PU has decreased size | third instar larval stage phenotype, non-enhanceable by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^repo.PU has decreased cell size | third instar larval stage phenotype, non-enhanceable by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

NOT suppressed by

Statement

Reference

Myc^GD1419, Scer\GAL4^repo.PU has decreased size | third instar larval stage phenotype, non-suppressible by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^repo.PU has decreased cell size | third instar larval stage phenotype, non-suppressible by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^ptc-559.1 has abnormal size | larval stage phenotype, non-suppressible by HUWE1^EY01689, Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

Suppressor of

Statement

Reference

Myc^GD1419, Scer\GAL4^repo is a suppressor | partially of abnormal wound healing | larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Scer\GAL4^Tub.PU/Myc^GD1419 is a suppressor of abnormal cell polarity | somatic clone - Minute background phenotype of l(2)gl⁴

(Froldi et al., 2010)

Scer\GAL4^Tub.PU/Myc^GD1419 is a suppressor of increased cell number | somatic clone - Minute background phenotype of l(2)gl⁴

(Froldi et al., 2010)

Myc^GD1419, Scer\GAL4^αTub84B.PP is a suppressor of hyperplasia | somatic clone phenotype of Scer\GAL4^αTub84B.PP, yki^UAS.cHa

(Ziosi et al., 2010)

Other

Statement

Reference

HUWE1^GD13830, Myc^GD1419, Scer\GAL4^Hey.PO has decreased cell size phenotype

(Yanku et al., 2018)

Myc^GD1419, Scer\GAL4^αTub84B.PP, yki^UAS.cHa has decreased cell number | somatic clone phenotype

(Ziosi et al., 2010)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Myc^GD1419, Scer\GAL4^repo.PU has larval brain | third instar larval stage phenotype, non-enhanceable by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^repo.PU has nucleolus | third instar larval stage phenotype, non-enhanceable by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^repo.PU has larval neuroblast | third instar larval stage | decreased number phenotype, non-enhanceable by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^repo.PU has larval glial cell | third instar larval stage | decreased number phenotype, non-enhanceable by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

NOT suppressed by

Statement

Reference

Myc^GD1419, Scer\GAL4^repo.PU has larval brain | third instar larval stage phenotype, non-suppressible by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^repo.PU has nucleolus | third instar larval stage phenotype, non-suppressible by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^repo.PU has larval neuroblast | third instar larval stage | decreased number phenotype, non-suppressible by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^repo.PU has larval glial cell | third instar larval stage | decreased number phenotype, non-suppressible by Wdr62^UAS.Tag:HA, Scer\GAL4^repo.PU

(Shohayeb et al., 2020)

Myc^GD1419, Scer\GAL4^ptc-559.1 has embryonic/larval salivary gland | larval stage phenotype, non-suppressible by HUWE1^EY01689, Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

Suppressor of

Statement

Reference

Myc^GD1419, Scer\GAL4^repo is a suppressor | partially of larval multidendritic class IV neuron phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Scer\GAL4^Tub.PU/Myc^GD1419 is a suppressor of wing disc | somatic clone - Minute background phenotype of l(2)gl⁴

(Froldi et al., 2010)

Scer\GAL4^Tub.PU/Myc^GD1419 is a suppressor of basement membrane | somatic clone - Minute background phenotype of l(2)gl⁴

(Froldi et al., 2010)

NOT Suppressor of

Statement

Reference

Myc^GD1419, Scer\GAL4^sd-SG29.1 is a non-suppressor of dorsal-ventral compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^sd-SG29.1, mir-ban^C.UAS.EGFP

(Becam et al., 2011)

Other

Statement

Reference

HUWE1^GD13830, Myc^GD1419, Scer\GAL4^Hey.PO has embryonic/larval salivary gland | larval stage phenotype

(Yanku et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of HUWE1^GD13830 and Myc^GD1419 under the control of Scer\GAL4^Hey.PO (in combination with Dicer-2, for an efficient RNAi) results in small cells in the larval salivary gland.

(Yanku et al., 2018)

Expression of dm^GD1419 is unable to suppress the dorsal-ventral boundary defects seen when ban^{C.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^sd-SG29.1.

(Becam et al., 2011)

Expression of Myc^GD1419 under the control of Scer\GAL4^tub.PU suppresses the cell polarity defects seen in l(2)gl⁴ mutant wing disc clones generated in a Minute background, even when the mutant clone tissue occupies a larger proportion of the disc. No degradation of the basement membrane occurs and clones do not form tumorous masses, either in the wing pouch or proximal (hinge and pleura) regions.

(Froldi et al., 2010)

Xenogenetic Interactions

Statement

Reference

Expression of BacA\p35^Scer\UAS.cHa in wing disc clones expressing dm^GD1419 under the control of Scer\GAL4^Act5C.PP results in reduced nucleolar cell size. Mutant cells display a rounded-morphology.

(Mitchell et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v2947

w¹¹¹⁸; P{GD1419}v2947

v2948

w¹¹¹⁸; P{GD1419}v2948