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General Information
Symbol
Dmel\grpGD4189
Species
D. melanogaster
Name
FlyBase ID
FBal0209661
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adults expressing grpGD4189 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The small and deformed wings in adult flies expressing His1:CG31617NIG.31617R under the control of Scer\GAL4nub.PU are significantly suppressed by co-expression of grpGD4189.

The small, depigmented-eye phenotype of flies expressing PEKScer\UAS.cMa under the control of Scer\GAL4GMR.PF is partially suppressed by co-expression of grpGD4189.

Xenogenetic Interactions
Statement
Reference

The co-expression of grpGD4189 enhances the enlarged wing disc posterior compartment observed upon exposure to ionizing radiation of individuals expressing BacA\p35UAS.cHa under the control of Scer\GAL4en.PU.

The Scer\GAL4en.PU-driven co-expression of BacA\p35UAS.cHa and grpGD4189 leads to a longer sustained DNA damage response to ionizing ration (assessed by phospho-H2Av immunostaining) in the wing disc posterior compartment as compared to the BacA\p35UAS.cHa single expression or wild-type backgrounds.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
grpGD4189
Name Synonyms
Secondary FlyBase IDs
    References (9)