FB2025_01 , released February 20, 2025
Allele: Dmel\httGD14339
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General Information
Symbol
Dmel\httGD14339
Species
D. melanogaster
Name
FlyBase ID
FBal0209708
Feature type
allele
Associated gene
Dmel\htt
Associated Insertion(s)
Carried in Construct
P{GD14339}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD14339}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD14339
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Huntington's disease
      CEA
      (Gonzales and Yin, 2010)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Sleep disturbances are a clinical feature of Huntington's Disease. Flies expressing httGD14339 pan-neuronally show fragmentation of nighttime sleep.

      (Gonzales and Yin, 2010)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing httGD14339 under the control of Scer\GAL4elav.PU show a decrease in total nighttime sleep. Nighttime sleep is fragmented in these files compared to controls (average and maximum sleep bout length are reduced, and the number of sleep bouts is increased). This fragmentation of nighttime sleep is seen within the first 5 days of eclosion. Daytime sleep is unaffected in these flies.

      (Gonzales and Yin, 2010)

      Adults expressing httGD14339 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Scer\GAL4en.PU/httGD14339 is an enhancer of visible phenotype of Scer\GAL4en.PU, Su(var)3-3GD9296

      (Dietz et al., 2015)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Scer\GAL4en.PU/httGD14339 is an enhancer of wing vein phenotype of Scer\GAL4en.PU, Su(var)3-3GD9296

      (Dietz et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ovarian defects observed in females expressing Su(var)3-3GD9296 under the control of Scer\GAL4Act5C.PI as well as the ectopic venation phenotype induced by Scer\GAL4en.PU-driven expression of Su(var)3-3GD9296 are enhanced by co-expression of httGD14339.

      (Dietz et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      httGD14339
      Name Synonyms
      Secondary FlyBase IDs
        References (9)