FB2025_01 , released February 20, 2025
Allele: Dmel\Ire1GD3071
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General Information
Symbol
Dmel\Ire1GD3071
Species
D. melanogaster
Name
FlyBase ID
FBal0209742
Feature type
allele
Associated gene
Dmel\Ire1
Associated Insertion(s)
Carried in Construct
P{GD3071}
Also Known As
Ire1-Ri, UAS-IRE1RNAi, ire1 RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD3071}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD3071
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Ire1GD3071 under the control of Scer\GAL4Ddc.PU does not affect lifespan, adult climbing ability or number of DA neurons.

      (Yan et al., 2019)

      The expression of Ire1GD3071 under the control of Scer\GAL4c564 blocks the normal inflammatory response to both Gram-positive (assessed by the expression levels of Drosomycin) and Gram-negative (assessed by the expression levels of Diptericin) bacterial infection, while leading to a mild but ectopic inflammatory response in basal (non-infected) conditions, as compared to controls.

      (Kumar et al., 2016)

      Adults expressing Ire1GD3071 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      Suppressor of
      Other
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of Ire1GD3071 enhances the eye defects induced by the expression of Hsap\PRNPV129.UAS under the control of Scer\GAL4GMR.PU, even leading to a small eye.

      (Myers et al., 2022)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      IRE1RNAi
      (Wang et al., 2015)
      Ire1GD3071
      ire-1GD3071
      Name Synonyms
      Secondary FlyBase IDs
        References (20)