FlyBase Allele Report: Dmel\jbug[GD13033]

General Information

Symbol

Dmel\jbug^GD13033

Species

D. melanogaster

Name

FlyBase ID

FBal0209750

Feature type

allele

Associated gene

Dmel\jbug

Associated Insertion(s)

Carried in Construct

P{GD13033}

Also Known As

GD13033

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD13033}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD13033

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

axon | adult stage, with Scer\GAL4^GMR.PU

(Oliva et al., 2015)

denticle | decreased number | embryonic stage 16, with Scer\GAL4^da.G32

(Chung et al., 2021)

denticle | embryonic stage 16, with Scer\GAL4^da.G32

(Chung et al., 2021)

embryonic epidermis | embryonic stage 16, with Scer\GAL4^da.G32

(Chung et al., 2021)

eye photoreceptor cell | adult stage, with Scer\GAL4^GMR.PU

(Oliva et al., 2015)

Detailed Description

Statement

Reference

Stage 16 embryos expressing jbug^GD13033 under the control of Scer\GAL4^da.G32 exhibit fewer denticles in the epidermis.

(Chung et al., 2021)

Expression of jbug^GD13033 driven by Scer\GAL4^GMR.PU leads to significant mistargeting and overshooting of R1-R6 axons towards the medulla layers, compared to controls; few R7 axons pass through M6 and target deeper layers of the medulla.

(Oliva et al., 2015)

Flies expressing jbug^GD13033 under the control of Scer\GAL4^pnr-MD237 have anterior indentations in the notal cuticle and show planar polarity defects in the notum.

(Olguín et al., 2011)

Adults expressing jbug^GD13033 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in planar polarity defects in the orientation of bristles of the notum in 50-60% or 60-70% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 0% or 20-30% of the Scer\GAL4^pnr-MD237-expressing area of the notum, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

13033

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, jbug^GD13033 has abnormal planar polarity phenotype, enhanceable by chas^GD7593/Scer\GAL4^pnr-MD237

(Olguín et al., 2011)

Enhancer of

Statement

Reference

jbug^GD13033/Scer\GAL4^pnr-MD237 is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^pnr-MD237, chas^GD7593

(Olguín et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, jbug^GD13033 has mesonotum phenotype, enhanceable by chas^GD7593/Scer\GAL4^pnr-MD237

(Olguín et al., 2011)

Enhancer of

Statement

Reference

jbug^GD13033/Scer\GAL4^pnr-MD237 is an enhancer of mesonotum phenotype of Scer\GAL4^pnr-MD237, chas^GD7593

(Olguín et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of jbug^GD13033 and chas^GD7593 under the control of Scer\GAL4^pnr-MD237 results in enhanced indentations of the anterior notum epidermis and enhanced planar polarity defects compared to either single mutant.

(Olguín et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v28471

w¹¹¹⁸; P{GD13033}v28471

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

13033

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

jbug^GD13033

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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