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General Information
Symbol
Dmel\ND-SGDHGD3876
Species
D. melanogaster
Name
FlyBase ID
FBal0209888
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

5-week old flies expressing ND-SGDHGD3876 under the control of Scer\GAL4Hand.PU and subjected to ad libitum feeding (ARF) have improved cardiac physiology compared to controls.

Adults expressing ND-SGDHGD3876 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Ubiquitous expression using Scer\GAL4Switch.tub, induced during larval development and adulthood, prolongs life span in female flies and has variable effects on male life span. Female fertility is reduced. Flies also show improved tolerance to paraquat poisoning, but do not show improved starvation resistance. Developmental time, climbing ability, adult size and mass are all unaffected.

Ubiquitous expression using Scer\GAL4Switch.tub from the onset of adulthood only also increases female life span and has variable effects on males. Female fertility is also reduced.

Constitutive or adult only neuronal expression using Scer\GAL4elav.Switch.PO increases mean life span in females and has variable effects in males. Adult only neuronal expression does not significantly affect female fertility.

Under rich nutritional conditions the lifespan of l(3)neo18GD3876 knockdown flies (under the control of Scer\GAL4Act5C.Switch.PR and RU486) is indistinguishable from control flies. However, upon dietary restriction, knockdown diminishes lifespan extension in both male and female flies compared to their respective controls.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ND-SGDHGD3876
l(3)neo18GD3876
Name Synonyms
Secondary FlyBase IDs
    References (10)