Open Close
General Information
Symbol
Dmel\mbcGD6965
Species
D. melanogaster
Name
FlyBase ID
FBal0210050
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adult glia expressing mbcGD6965 (through Scer\GAL4repo and Scer\GAL80ts.αTub84B) exhibit reduced recruitment of glial cells to severed axons, resulting in a delay in axonal debris clearance.

Expression of mbcGD6965 under the control of Scer\GAL4alrm.PD results in a mild suppression of mushroom body γ neuron pruning at 18 hours after pupal formation and a mild phenotype in adults.

The expression of mbcGD6965 under the control of Scer\GAL4srp.Hemo does not affect the competence of embryonic hemocytes of undertaking phagocytosis of apoptotic cells, as compared to controls.

The expression of mbcGD6965 under the control of Scer\GAL4Act5C.PI leads to near lethality.

Adults expressing mbcGD6965 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in late pupal lethality.

Expression under the control of Scer\GAL4pnr-MD237 results in extra bristles on the notum in 30-40% of the Scer\GAL4pnr-MD237 expression domain.

Expression under the control of Scer\GAL4pnr-MD237 results in an enlarged notum.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Adult glia expressing SosGD1539 and mbcGD6965 (through Scer\GAL4repo and Scer\GAL80ts.αTub84B) exhibit complete blockage of glial recruitment to axonal injury sites. This results in the accumulation of axonal debris and a glial hypertrophy response.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
mbcGD6965
Name Synonyms
Secondary FlyBase IDs
    References (11)