Allele Dmel\mod(mdg4)^GD16547

General Information
Symbol	Dmel\mod(mdg4)^GD16547	Species	D. melanogaster
Name		FlyBase ID	FBal0210093
Feature type	allele	Associated gene	Dmel\mod(mdg4)

Map ( GBrowse )
Allele class
Mutagen	in vitro construct - RNAi, in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Dickson et al., 2007.7.18) in vitro construct - RNAi (Dickson et al., 2007.7.18)
Mutations Mapped to the Genome

Type Location Additional Notes References RNAi reagent :57..347 :1..56
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of an inverted repeat. (Dickson et al., 2007.7.18)
Carried in construct	P{GD16547} (Dickson et al., 2007.7.18, Richter et al., 2011, van Eyk et al., 2011)
Associated Sequence Features	dsRNA-GD16547
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference mod(mdg4)^GD16547/Scer\GAL4^GMR.PFa is an enhancer of visible phenotype of Scer\GAL4^GMR.PFa, Zzzz\CAG^{93.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} (van Eyk et al., 2011) mod(mdg4)^GD16547/Scer\GAL4^GMR.PFa is an enhancer of visible phenotype of Scer\GAL4^GMR.PFa, Zzzz\CAG^{CAA.94.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} (van Eyk et al., 2011) mod(mdg4)^GD16547/Scer\GAL4^GMR.PFa is an enhancer of visible phenotype of Scer\GAL4^GMR.PFa, Zzzz\CTG^{86.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} (van Eyk et al., 2011)
Suppressor of
Statement Reference mod(mdg4)^GD16547/Scer\GAL4^GMR.PFa is a suppressor \| partially of viable phenotype of Scer\GAL4^GMR.PFa, Zzzz\CAG^{93.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} (van Eyk et al., 2011)
Other
Statement Reference Scer\GAL4^GMR.PFa, Zzzz\CTG^{term.CTG.99.Scer\UAS}, mod(mdg4)^GD16547 has visible phenotype (van Eyk et al., 2011)
Phenotype Manifest In
Enhancer of
Statement Reference mod(mdg4)^GD16547/Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Zzzz\CAG^{93.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} (van Eyk et al., 2011) mod(mdg4)^GD16547/Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Zzzz\CAG^{CAA.94.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} (van Eyk et al., 2011) mod(mdg4)^GD16547/Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Zzzz\CTG^{86.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG} (van Eyk et al., 2011)
Other
Statement Reference Scer\GAL4^GMR.PFa, Zzzz\CTG^{term.CTG.99.Scer\UAS}, mod(mdg4)^GD16547 has eye phenotype (van Eyk et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Co-expression of mod(mdg4)[GD16547] with Zzzz\CAG[93.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG] under the control of Scer\GAL4[GMR.PFa] results in an enhancement of the Zzzz\CAG[93.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG]-induced eye phenotype and a reduction in viability of the flies. Co-expression of mod(mdg4)[GD16547] with Zzzz\CAG[CAA.94.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG] under the control of Scer\GAL4[GMR.PFa] results in a mild enhancement of the Zzzz\CAG[CAA.94.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG]-induced eye pigmentation defects. Co-expression of mod(mdg4)[GD16547] with Zzzz\CTG[86.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG] under the control of Scer\GAL4[GMR.PFa] results in the enhancement of the Zzzz\CTG[86.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG]-induced eye phenotype. Co-expression of mod(mdg4)[GD16547] with Zzzz\CTG[term.CTG.99.Scer\UAS] under the control of Scer\GAL4[GMR.PFa] results in a marked disruption of the pigmentation and patterning of the eye. Co-expression of mod(mdg4)[GD16547] with Zzzz\CAG[term93.Scer\UAS] under the control of Scer\GAL4[GMR.PFa] does not disrupt eye patterning. Co-expression of mod(mdg4)[GD16547] with Zzzz\CAG[term.CAA.114.Scer\UAS] under the control of Scer\GAL4[GMR.PFa] does not disrupt eye patterning. Co-expression of mod(mdg4)[GD16547] with Hsap\ATXN10[rAUUCU.65.Scer\UAS] under the control of Scer\GAL4[GMR.PFa] does not disrupt eye patterning. (van Eyk et al., 2011)
Complementation & Rescue Data
Comments
Stocks ( 1 )
VDRC	v52268 w¹¹¹⁸ P{GD16547}v52268
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	mod(mdg4)^GD16547
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] van Eyk et al., 2011, Hum. Mol. Genet. 20(14): 2783--2794 Perturbation of the Akt/Gsk3-{beta} signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. [FBrf0213942]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]

Allele Dmel\mod(mdg4)GD16547

Allele Dmel\mod(mdg4)^GD16547