FlyBase Allele Report: Dmel\salm[GD1525]

General Information

Symbol

Dmel\salm^GD1525

Species

D. melanogaster

Name

FlyBase ID

FBal0210505

Feature type

allele

Associated gene

Dmel\salm

Associated Insertion(s)

Carried in Construct

P{GD1525}

Also Known As

salm-IR, UAS-salm-i

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1525}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1525

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^phtm.PO

(Ostalé et al., 2024)

flightless, with Scer\GAL4^Mef2.PR

(Schönbauer et al., 2011, Schnorrer et al., 2010)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schönbauer et al., 2011)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of salm^GD1525 under the control of Scer\GAL4^Mef2.PR results in a complete tubular conversion of the indirect flight muscles.

(Spletter et al., 2015)

Expression of salm^GD1525 under the control of Scer\GAL4^Mef2.PR leads to viable but flightless animals with a reduced number of dorsal-longitudinal muscles (DLMs). The mutant indirect flight muscles display abnormal fibre organization. Instead of the fibrillar indirect flight muscle morphology with distinct, unaligned myofibrils and nuclei located between the fibrils, these muscles show a tubular fibre-type morphology normally found in leg muscles, with aligned myofibrils and nuclei located in the tube centre. Leg muscles are normal in animals expressing salm^GD1525 under the control of Scer\GAL4^Mef2.PR.

(Schönbauer et al., 2011)

Adults expressing salm^GD1525 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in missing adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in morphologically wild-type myofibrils in the adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the adult indirect flight muscles.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development