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General Information
Symbol
Dmel\Sec6GD11616
Species
D. melanogaster
Name
FlyBase ID
FBal0210552
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Sec6GD11616 driven by Scer\GAL4phm.PO leads to developmental delay/arrest at the larval stage.

Eye-antennal disc clones expressing Sec6GD11616 under the control of Scer\GAL4Act.PU are smaller than controls.

RNAi-mediated reduction in Sec6, through expression of Sec6GD11616 under the control of Scer\GAL4dpp.blk1 leads to growth retardation in the wing disc.

Adults expressing Sec6GD11616 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in a weak flyer phenotype or late pupal lethality.

Expression under the control of Scer\GAL4pnr-MD237 results in lethality before the pupal stage or semi-lethality during the adult stage, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in external sensory organs consisting of empty or multiple sockets in 30-40% of the Scer\GAL4pnr-MD237 expression domain of the notum.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 70-80% of the Scer\GAL4pnr-MD237-expressing area of the notum.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Sec6GD11616 suppresses the overgrowth phenotype and pupal lethality seen in eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Sec6GD11616
sec6GD11616
Name Synonyms
Secondary FlyBase IDs
    References (8)