FB2025_02 , released April 17, 2025
Allele: Dmel\Sec6GD11616
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General Information
Symbol
Dmel\Sec6GD11616
Species
D. melanogaster
Name
FlyBase ID
FBal0210552
Feature type
allele
Associated gene
Dmel\Sec6
Associated Insertion(s)
Carried in Construct
P{GD11616}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD11616}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD11616
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by Ras85DV12.UAS
      (Chabu and Xu, 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sec6GD11616 driven by Scer\GAL4phm.PO leads to developmental delay/arrest at the larval stage.

      (Yamanaka et al., 2015)

      Eye-antennal disc clones expressing Sec6GD11616 under the control of Scer\GAL4Act.PU are smaller than controls.

      (Chabu and Xu, 2014)

      RNAi-mediated reduction in Sec6, through expression of Sec6GD11616 under the control of Scer\GAL4dpp.blk1 leads to growth retardation in the wing disc.

      (Michel et al., 2011)

      Adults expressing Sec6GD11616 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in a weak flyer phenotype or late pupal lethality.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in lethality before the pupal stage or semi-lethality during the adult stage, depending on the insertion line used.

      Expression under the control of Scer\GAL4pnr-MD237 results in external sensory organs consisting of empty or multiple sockets in 30-40% of the Scer\GAL4pnr-MD237 expression domain of the notum.

      Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 70-80% of the Scer\GAL4pnr-MD237-expressing area of the notum.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Sec6GD11616, Scer\GAL4Act.PU is a suppressor of eye disc | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU

      (Chabu and Xu, 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Sec6GD11616 suppresses the overgrowth phenotype and pupal lethality seen in eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

      (Chabu and Xu, 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sec6GD11616
      sec6GD11616
      Name Synonyms
      Secondary FlyBase IDs
        References (9)