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General Information
Symbol
Dmel\sip3GD3145
Species
D. melanogaster
Name
FlyBase ID
FBal0210589
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Hrd1 RNAi
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of sip3GD3145 under the combined control of Scer\GAL4GMR.PU, Scer\GAL4ey.PU and Dicer-2 (for efficient RNAi) does not lead to any obvious eye morphology defects, as compared to controls.

Adults expressing sip3GD3145 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The abnormal eye morphology resulting from the expression of ninaEG69D.GMR under the combined control of Scer\GAL4GMR.PU, Scer\GAL4ey.PU is not suppressed by the co-expression of sip3Scer\UAS.T:Hsap\MYC and sip3GD3145 (together with Dicer-2, for efficient RNAi).

Expression of sip3GD3145 enhances the rough eye phenotype and underlying photoreceptor degeneration seen when TER94A229E.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.

Expression of sip3GD3145 does not reverse the suppressive effect of Der-1Scer\UAS.cLa on the rough eye and photoreceptor degeneration phenotypes seen when TER94R188Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.

Expression of sip3GD3145 suppresses the rough eye phenotype seen when styScer\UAS.N.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PF.

Expression of sip3GD3145 suppresses the rough eye phenotype seen when aosScer\UAS.cHa is expressed under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference

Co-expression of sip3GD3145 enhances eye degeneration in Scer\GAL4GMR.long>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 flies. Co-expression of sip3GD3145 does not suppress the protective role of expression of Hsap\ATXN3Scer\UAS.WT.T:Zzzz\His6 in suppression of eye degeneration in Scer\GAL4GMR.long>Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 flies.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
sip3GD3145
Name Synonyms
Secondary FlyBase IDs
    References (14)