FlyBase Allele Report: Dmel\trbl[GD11640]

General Information

Symbol

Dmel\trbl^GD11640

Species

D. melanogaster

Name

FlyBase ID

FBal0210791

Feature type

allele

Associated gene

Dmel\trbl

Associated Insertion(s)

Carried in Construct

P{GD11640}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11640}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11640

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^ppl.PP

(Das et al., 2014)

abnormal developmental rate | larval stage, with Scer\GAL4^r4

(Fischer et al., 2017)

abnormal size | larval stage, with Scer\GAL4^ppl.PP

(Das et al., 2014)

abnormal size | larval stage, with Scer\GAL4^r4

(Fischer et al., 2017)

increased cell death | third instar larval stage, with Scer\GAL4^en-e16E

(Sun et al., 2020)

increased cell size, with Scer\GAL4^ppl.PP

(Das et al., 2014)

increased cell size | larval stage, with Scer\GAL4^r4

(Fischer et al., 2017)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

border follicle cell, with Scer\GAL4^slbo.2.6

(Masoner et al., 2013)

embryonic/larval fat body | larval stage, with Scer\GAL4^r4

(Fischer et al., 2017)

fat body, with Scer\GAL4^ppl.PP

(Das et al., 2014)

fat cell | larval stage, with Scer\GAL4^r4

(Fischer et al., 2017)

nucleus | larval stage, with Scer\GAL4^r4

(Fischer et al., 2017)

wing disc | third instar larval stage, with Scer\GAL4^en-e16E

(Sun et al., 2020)

Detailed Description

Statement

Reference

Expression of trbl^GD11640 under the control of Scer\GAL4^en-e16E leads to increased cell death in third instar larval wing discs.

(Sun et al., 2020)

Larvae expressing trbl^GD11640 under the control of Scer\GAL4^r4 does not show changes in body weight; larval fat body cells and their lipid droplets are significantly larger than in controls, but their nuclei are significantly smaller than in controls; there is a delay to pupariation.

The expression of trbl^GD11640 under the control of Scer\GAL4^en-e16E does not lead to obvious changes in wing size or wing size:trichome density ratio, as compared to controls.

(Fischer et al., 2017)

Expression of trbl^GD11640 in the fat body under the control of Scer\GAL4^ppl.PP results in a significant increase in both larval weight and fat body cell size relative to controls. Pupariation is advanced compared with controls. Circulating glucose and trehalose levels are similar to controls but there is a significant increase in total triglyceride levels.

Expression of trbl^GD11640 in the fat body under the control of Scer\GAL4^ppl.PP results in a significant increase in the number and size of lipid drops.

(Das et al., 2014)

Expression of trbl^GD11640 under the control of Scer\GAL4^slbo.2.6 partially blocks border cell migration.

(Masoner et al., 2013)

Adults expressing trbl^GD11640 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11640

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v22113

w¹¹¹⁸; P{GD11640}v22113

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11640

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

trbl^GD11640

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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