FB2025_01 , released February 20, 2025
Allele: Dmel\timmTimL
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General Information
Symbol
Dmel\timmTimL
Species
D. melanogaster
Name
FlyBase ID
FBal0212159
Feature type
allele
Associated gene
Dmel\tim
Associated Insertion(s)
Carried in Construct
P{L-tim}
Also Known As
P[L-tim]
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Tauber et al., 2007)
Progenitor genotype
timmTim4
(Tauber et al., 2007)
Carried in construct
P{L-tim}
Cytology
Description

Nucleotide substitution: A311G.

(Tauber et al., 2007)

The genomic tim promoter drives expression of a mutated tim cDNA, in which the ATG start codon at position 311-313 is mutated to GGG so that only the long tim isoform can be expressed from this transgene. This construct is modified from the timmTim4 construct; a SwaI-KpnI fragment containing the mutated cDNA has replaced the SwaI-KpnI fragment of timmTim4.

(Tauber et al., 2007)

Nucleotide substitution: T312G.

(Tauber et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
tim
Encoded product / tool
tim
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      timmTimL flies kept in constant light conditions show locomotor arrhythmicity, as do wild-type flies.

      (Sandrelli et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      timmTimL partially rescues tim01

      (Tauber et al., 2007)
      Comments

      Expression of timmTimL results in significant rescue of the arrhythmic tim01 locomotor phenotype in males.

      (Tauber et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      timmTimL
      Name Synonyms
      Secondary FlyBase IDs
        References (3)