FB2025_01 , released February 20, 2025
Allele: Dmel\Su(var)205RNAi.Sym.UAS
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General Information
Symbol
Dmel\Su(var)205RNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0212197
Feature type
allele
Associated gene
Dmel\Su(var)205
Associated Insertion(s)
Carried in Construct
P{Sym-UAS-Su(var)205}
Key Links
Transgenic product class
RNAi_reagent
(Liu et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Liu et al., 2005)
Mutagen
in vitro construct
(Liu et al., 2005)
Progenitor genotype
Carried in construct
P{Sym-UAS-Su(var)205}
Cytology
Description

Sense-antisense transcription (driven by two convergent arrays of UAS regulatory sequences) of a 617bp fragment of Su(var)205 coding sequence results in double stranded RNA (dsRNA) expression.

(Liu et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Su(var)205
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Su(var)205dsRNA.Sym.Scer\UAS under the control of Scer\GAL4Act.PU results mainly in pupal lethality. Adult escapers are mostly female.

      Expression of Su(var)205dsRNA.Sym.Scer\UAS under the control of Scer\GAL4en-e16E results in increased cell death in wing discs and missing parts of the posterior wing compartments.

      Expression of Su(var)205dsRNA.Sym.Scer\UAS under the control of Scer\GAL4ey.PH results in increased cell death in eye discs and reduced adult eyes.

      Neuroblasts that express Su(var)205dsRNA.Sym.Scer\UAS under the control of Scer\GAL4Act.PU show defective chromosomes; a phenotype that occurs approximately twice as much as males as in females.

      Expression of P{Sym-UAS-Su(var)205} (which carries both Su(var)205Sym.Scer\UAS and Su(var)205a.Sym.Scer\UAS) under the control of Scer\GAL4Act results mainly in pupal lethality. Adult escapers are mostly female.

      Expression of P{Sym-UAS-Su(var)205} (which carries both Su(var)205Sym.Scer\UAS and Su(var)205a.Sym.Scer\UAS) under the control of Scer\GAL4en-e16E results in increased cell death in wing discs and missing parts of the posterior wing compartments.

      Expression of P{Sym-UAS-Su(var)205} (which carries both Su(var)205Sym.Scer\UAS and Su(var)205a.Sym.Scer\UAS) under the control of Scer\GAL4ey.PH results in increased cell death in eye discs and reduced adult eyes.

      Neuroblasts that express P{Sym-UAS-Su(var)205} (Su(var)205Sym.Scer\UAS, Su(var)205a.Sym.Scer\UAS) under the control of Scer\GAL4Act show defective chromosomes; a phenotype that occurs approximately twice as much as males as in females.

      (Liu et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4ey.PH, Su(var)205RNAi.Sym.UAS has eye phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4ey.PH

      (Liu et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Su(var)205dsRNA.Sym.Scer\UAS, under the control of Scer\GAL4ey.PH, results in a partial suppression of the reduced eye phenotype seen in Scer\GAL4ey.PH>P{Sym-UAS-Su(var)205} flies.

      Co-expression of BacA\p35Scer\UAS.cHa with P{Sym-UAS-Su(var)205} (Su(var)205Sym.Scer\UAS, Su(var)205a.Sym.Scer\UAS), under the control of Scer\GAL4ey.PH, results in a partial suppression of the reduced eye phenotype seen in Scer\GAL4ey.PH>P{Sym-UAS-Su(var)205} flies.

      (Liu et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Su(var)205RNAi.Sym.UAS
      Su(var)205Sym.Scer\UAS
      Su(var)205dsRNA.Sym.Scer\UAS
      Su(var)205dsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0212198
      References (3)