Allele Dmel\Su(var)205^{dsRNA.Sym.Scer\UAS}

General Information
Symbol	Dmel\Su(var)205^{dsRNA.Sym.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0212197
Feature type	allele	Associated gene	Dmel\Su(var)205

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - RNAi
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Liu et al., 2005) in vitro construct - RNAi (Liu et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Sense-antisense transcription (driven by two convergent arrays of Scer\UAS promoter and regulatory sequences) of a 617 bp fragment of Su(var)205 coding sequence results in double stranded RNA (dsRNA) expression. (Liu et al., 2005)
Carried in construct	P{Sym-UAS-Su(var)205} (Liu et al., 2005, Johansson et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pupal stage, with Scer\GAL4^Act.PU (Liu et al., 2005)
Phenotype Manifest In
	eye, with Scer\GAL4^ey.PH (Liu et al., 2005) eye disc, with Scer\GAL4^ey.PH (Liu et al., 2005) neuroblast, with Scer\GAL4^Act.PU (Liu et al., 2005) wing \| posterior, with Scer\GAL4^en-e16E (Liu et al., 2005) wing disc, with Scer\GAL4^en-e16E (Liu et al., 2005)
Detailed Description
	Statement Reference Expression of Su(var)205[dsRNA.Sym.Scer\UAS] under the control of Scer\GAL4[Act.PU] results mainly in pupal lethality. Adult escapers are mostly female. Expression of Su(var)205[dsRNA.Sym.Scer\UAS] under the control of Scer\GAL4[en-e16E] results in increased cell death in wing discs and missing parts of the posterior wing compartments. Expression of Su(var)205[dsRNA.Sym.Scer\UAS] under the control of Scer\GAL4[ey.PH] results in increased cell death in eye discs and reduced adult eyes. Neuroblasts that express Su(var)205[dsRNA.Sym.Scer\UAS] under the control of Scer\GAL4[Act.PU] show defective chromosomes; a phenotype that occurs approximately twice as much as males as in females. (Liu et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^ey.PH, Su(var)205^{dsRNA.Sym.Scer\UAS}, Su(var)205^{a.Sym.Scer\UAS} has eye phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^ey.PH (Liu et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Co-expression of Su(var)205[dsRNA.Sym.Scer\UAS], under the control of Scer\GAL4[ey.PH], results in a partial suppression of the reduced eye phenotype seen in Scer\GAL4[ey.PH]>P{Sym-UAS-Su(var)205} flies. (Liu et al., 2005)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Su(var)205^{dsRNA.Sym.Scer\UAS} Su(var)205^Sym.Scer\UAS
Name Synonym
Secondary FlyBase IDs
	FBal0212198
References ( 2 )
Research paper	Johansson et al., 2007, EMBO J. 26(9): 2307--2316 Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster. [FBrf0202200] Liu et al., 2005, Nat. Genet. 37(12): 1361--1366 Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. [FBrf0191273]

Allele Dmel\Su(var)205dsRNA.Sym.Scer\UAS

Allele Dmel\Su(var)205^{dsRNA.Sym.Scer\UAS}