FlyBase Allele Report: Dmel\ball[E107]

General Information

Symbol

Dmel\ball^E107

Species

D. melanogaster

Name

FlyBase ID

FBal0212319

Feature type

allele

Associated gene

Dmel\ball

Associated Insertion(s)

Carried in Construct

Also Known As

nhk-1^E107

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Cullen et al., 2005)

Progenitor genotype

ball^EP863

(Cullen et al., 2005)

Cytology

Description

Imprecise excision of P{EP}ball^EP863 generates a 1.1kb deletion of the genomic region corresponding to the kinase domain of ball and is therefore considered a kinase-null mutation.

(Cullen et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates primary autosomal recessive microcephaly 16

modeled by Ankle2^A

(Link et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

central nervous system | third instar larval stage

(Nikalayevich and Ohkura, 2015)

chromosome | third instar larval stage

(Nikalayevich and Ohkura, 2015)

condensed chromosome

(Cullen et al., 2005)

imaginal disc

(Cullen et al., 2005)

larval brain

(Cullen et al., 2005)

larval central nervous system

(Cullen et al., 2005)

Detailed Description

Statement

Reference

ball^E107 heterozygotes are viable.

(Link et al., 2019)

ball^E107 homozygous third instar larvae display chromosome condensation defects in the mitotic cells in the central nervous system (the same undercondensed chromosome phenotype is observed also in samples treated with colchicine), the frequency of mitotic cells (phospho-histone H3-positive) is significantly decreased compared to wild-type.

(Nikalayevich and Ohkura, 2015)

ball^E107 homozygotes die as early pupae. The mutant larvae grow to the same size as wild-type with no obvious defects in behavior. However, dissection of larvae reveals that the imaginal discs are missing or degenerated and that the CNS is very small. Indeed the number of cells in the larval brain is greatly reduced. Furthermore, dividing cells are almost absent in most of the CNS examined from late third instar larvae. However, in some CNSs that contain mitotic cells, the mitotic chromosomes appear highly overcondensed.

(Cullen et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ball[+]/ball^E107 is a suppressor of lethal - all die before end of pupal stage | temperature conditional phenotype of Ankle2^A

(Link et al., 2019)

ball[+]/ball^E107 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^Act5C.PI, ZIKV\NS4A^UAS.Tag:HA