Open Close
General Information
Symbol
Dmel\Imp8
Species
D. melanogaster
Name
FlyBase ID
FBal0212707
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Excision of P{EP}ImpEP760 removes a large portion of the Imp-coding region (from the middle of intron 6 to exon 10).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In contrast to wild type, about 50% of Imp8 γ axons (generated via MARCM) fail to reach the end of the medial lobe. These defects do not result from axon retraction, and mutant axons of normal length but lost directionality are observed. Mutant neurons also exhibit an overall decrease in the complexity of axonal arborization patterns, characterized by a reduced number of terminal branches.

Class I abdominal dorsal multidendritic ddaD and ddaE neurons of Imp8 hemizygous mutant third instar larvae show similar number of dendrite branch terminals, as compared to controls.

Class IV abdominal dorsal multidendritic ddaC neurons of Imp8 hemizygous mutant third instar larvae show significant decreases in the number and cumulative length of dendrite branch terminals, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

Imp[+]/Imp8 is an enhancer of eye phenotype of Ppt1UAS.cKa, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF

Additional Comments
Genetic Interactions
Statement
Reference

A Imp8/+ background enhances the visual system degeneration seen in Scer\GAL4GMR.PF, Ppt1Scer\UAS.cKa flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)