FB2025_01 , released February 20, 2025
Allele: Dmel\vgΔACT.UAS
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General Information
Symbol
Dmel\vgΔACT.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0212940
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of amino acids 171-335 of vg.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of vgΔACT.Scer\UAS under the control of Scer\GAL4vg.PU results in a loss of wing bristles and wing tissue. The severity of the phenotype varies from almost complete loss of the wing to small patches of missing bristles in the anterior margin and loss of wing tissue along the posterior margin.

Expression of vgΔACT.Scer\UAS under the control of Scer\GAL4ptc-559.1 results in a protruding eye phenotype. Bristles can occur at adjacent vertices of the ommatidium or they can be absent. Duplications of eye bristles are seen and in severe cases as many as three extra bristles at a single vertex are seen. The size of the eye bristles is also affected. Bristle defects are more frequent along the tip of the eye protrusion. Ommatidial defects, ranging from increases in size, to fusion of adjacent ommatidia, are seen.

Flies expressing vgΔACT.Scer\UAS under the control of Scer\GAL4ptc-559.1 have an ectopic cluster of cells between the lamina and the basal membrane that correlates with the location of the protrusion of the eye. The components of the optic lobe are present and appear normal in these flies.

Expression of vgΔACT.Scer\UAS under the control of Scer\GAL4ptc-559.1 can results in duplications of the T2 and T3 legs.

Expression of vgΔACT.Scer\UAS under the control of Scer\GAL4Dll-md23 results in leg truncations, with the severity varying from los of only a few metatarsals to the loss of all of the metatarsals, tarsus and tibia. Sharp bends in the femur or tibia are also sometimes seen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of sdScer\UAS.cSa rescues the bristle and wing margin phenotypes caused by expression of vgΔACT.Scer\UAS under the control of Scer\GAL4vg.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
vgΔACT.Scer\UAS
vgΔACT.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)