Allele Dmel\vg^{ΔACT.Scer\UAS}

General Information
Symbol	Dmel\vg^{ΔACT.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0212940
Feature type	allele	Associated gene	Dmel\vg

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - deletion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Garg et al., 2007) in vitro construct - regulatory fusion (Garg et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of amino acids 171-335 of vg. (Garg et al., 2007)
Carried in construct	P{UAS-vg.ΔACT} (Garg et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage, with Scer\GAL4^Act.PU (Garg et al., 2007) visible, with Scer\GAL4^Dll-md23 (Garg et al., 2007) visible, with Scer\GAL4^ptc-559.1 (Garg et al., 2007) visible, with Scer\GAL4^vg.PU (Garg et al., 2007)
Phenotype Manifest In
	anterior wing margin, with Scer\GAL4^vg.PU (Garg et al., 2007) eye, with Scer\GAL4^ptc-559.1 (Garg et al., 2007) femur, with Scer\GAL4^Dll-md23 (Garg et al., 2007) interommatidial bristle, with Scer\GAL4^ptc-559.1 (Garg et al., 2007) interommatidial bristle \| ectopic, with Scer\GAL4^ptc-559.1 (Garg et al., 2007) leg, with Scer\GAL4^Dll-md23 (Garg et al., 2007) mesothoracic leg \| ectopic, with Scer\GAL4^ptc-559.1 (Garg et al., 2007) metatarsus, with Scer\GAL4^Dll-md23 (Garg et al., 2007) metathoracic leg \| ectopic, with Scer\GAL4^ptc-559.1 (Garg et al., 2007) ommatidium, with Scer\GAL4^ptc-559.1 (Garg et al., 2007) posterior wing margin, with Scer\GAL4^vg.PU (Garg et al., 2007) tibia, with Scer\GAL4^Dll-md23 (Garg et al., 2007) unguis, with Scer\GAL4^Dll-md23 (Garg et al., 2007) wing blade, with Scer\GAL4^vg.PU (Garg et al., 2007)
Detailed Description
	Statement Reference Expression of vg^{ΔACT.Scer\UAS} under the control of Scer\GAL4^vg.PU results in a loss of wing bristles and wing tissue. The severity of the phenotype varies from almost complete loss of the wing to small patches of missing bristles in the anterior margin and loss of wing tissue along the posterior margin. Expression of vg^{ΔACT.Scer\UAS} under the control of Scer\GAL4^ptc-559.1 results in a protruding eye phenotype. Bristles can occur at adjacent vertices of the ommatidium or they can be absent. Duplications of eye bristles are seen and in severe cases as many as three extra bristles at a single vertex are seen. The size of the eye bristles is also affected. Bristle defects are more frequent along the tip of the eye protrusion. Ommatidial defects, ranging from increases in size, to fusion of adjacent ommatidia, are seen. Flies expressing vg^{ΔACT.Scer\UAS} under the control of Scer\GAL4^ptc-559.1 have an ectopic cluster of cells between the lamina and the basal membrane that correlates with the location of the protrusion of the eye. The components of the optic lobe are present and appear normal in these flies. Expression of vg^{ΔACT.Scer\UAS} under the control of Scer\GAL4^ptc-559.1 can results in duplications of the T2 and T3 legs. Expression of vg^{ΔACT.Scer\UAS} under the control of Scer\GAL4^Dll-md23 results in leg truncations, with the severity varying from los of only a few metatarsals to the loss of all of the metatarsals, tarsus and tibia. Sharp bends in the femur or tibia are also sometimes seen. (Garg et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^vg.PU, vg^{ΔACT.Scer\UAS} has visible phenotype, suppressible by sd^Scer\UAS.cSa/Scer\GAL4^vg.PU (Garg et al., 2007)
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^vg.PU, vg^{ΔACT.Scer\UAS} has wing blade phenotype, suppressible by sd^Scer\UAS.cSa/Scer\GAL4^vg.PU (Garg et al., 2007) Scer\GAL4^vg.PU, vg^{ΔACT.Scer\UAS} has wing phenotype, suppressible by sd^Scer\UAS.cSa/Scer\GAL4^vg.PU (Garg et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of sd^Scer\UAS.cSa rescues the bristle and wing margin phenotypes caused by expression of vg^{ΔACT.Scer\UAS} under the control of Scer\GAL4^vg.PU. (Garg et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	vg^{ΔACT.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Garg et al., 2007, Genetics 175(2): 659--669 Antagonizing scalloped with a novel vestigial construct reveals an important role for scalloped in Drosophila melanogaster leg, eye and optic lobe development. [FBrf0193374]

Allele Dmel\vgΔACT.Scer\UAS

Allele Dmel\vg^{ΔACT.Scer\UAS}