|Feature type||allele||Associated gene||Dmel\Hs6st|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Zygotic Hs6std770 mutants survive to the adult stage without showing obvious morphological defects. A fraction (39%) of maternal and zygotic Hs6std770 mutants exhibit abnormal tracheal development. Tracheal development is incomplete, revealed by the presence of large gaps in the dorsal trunks, as well as stalled tracheal branches. The migration defects in these embryos are observed in all primary branches, but most commonly in the dorsal branch and the dorsal trunk. Tracheal morphology is indistinguishable from that of wild-type embryos in the remaining 61% of embryos. Normal development of tracheoblasts is observed in the majority of Hs6std770 mutants, although the tracheoblast is slightly reduced in size in a small fraction (18%) of Hs6std770 mutant discs.
|Phenotype Manifest In|
Hs6st[d770] suppresses the increased chemosensory bristle phenotype observed at the anterior dorsal wing margin of Sulf1[ΔP1] mutant animals.
Embryos that are maternal and zygotic mutant for Hs6std770 and Hs2std267 are partial lethal during development. However, significant fractions of these null mutants survive to the adult stage without visible phenotypes. Hs2std267/Hs6std770 zygotic double mutants are completely lethal. Although invagination seems to occur normally in Hs2std267/Hs6std770 embryos, they exhibit several characteristic defects in branching morphogenesis. First, mutant tracheal precursor cells fail to migrate to form the primary branches. Second, clusters of mutant tracheal cells tend to extend dorsally and ventrally, forming long, skinny sacs of tracheal precursor cells of various sizes. Finally, approximately 16% of mutant embryos show fusion of the tracheal sacs to those in the neighboring segments.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 2 )|