FB2025_01 , released February 20, 2025
Allele: Dmel\Gyc76CD945A.UAS.Tag:MYC
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General Information
Symbol
Dmel\Gyc76CD945A.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0213075
Feature type
allele
Associated gene
Dmel\Gyc76C
Associated Insertion(s)
Carried in Construct
P{UAS-Gyc76C.D945A}
Also Known As
UAS-Gyc76CD945A
Key Links
Transgenic product class
missense_variant
(Ayoob et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ayoob et al., 2004)
Mutagen
in vitro construct
(Ayoob et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-Gyc76C.D945A}
Cytology
Description

Amino acid replacement: D945A.

(Ayoob et al., 2004)

UASt regulatory sequences drive expression of a mutated form of Gyc76C. The Gyc76C sequence has a D945A mutation and also has two Tag:MYC epitopes in place of the N-terminal signal sequence. The amino acid change is designed to disrupt the Gyc76C product's cyclase activity.

(Ayoob et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gyc76C
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Gyc76CD945A.UAS.Tag:MYC under the control of Scer\GAL4Cg.PA leads to an increase in the number of proliferating hemocytes in third instar larval hemolymph when compared to controls.

      (Iwashita et al., 2020)

      Expression of Gyc76CD945A.Scer\UAS.T:Hsap\MYC under the control of either the Scer\GAL4A9 or the Scer\GAL4hh.PU driver does not induce ectopic venation but on the contrary results in partial or complete loss of posterior crossvein in adult wings.

      (Schleede and Blair, 2015)

      Expression of Gyc76CD945A.Scer\UAS.T:Hsap\MYC in all neurons, driven by Scer\GAL4elav.PLu, perturbs motor and CNS axon guidance in embryos. For example, axons of the ISNb and SNa fail to reach their proper targets and the RP3 axon extends exuberantly in the cleft between muscles 6 and 7.

      (Ayoob et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Coexpression of the dominant negative Gyc76CD945A.Scer\UAS.T:Hsap\MYC transgene with plexAScer\UAS.cWa, under the control of Scer\GAL4elav.PLu, results in a partial suppression of the plexAScer\UAS.cWa-induced axon guidance phenotype.

      (Ayoob et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gyc76CD945A.Scer\UAS.T:Hsap\MYC
      Gyc76CD945A.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (5)