|Feature type||allele||Associated gene||Dmel\Apc2|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
Embryos maternally and zygotically mutant for Apc2 have an average cuticle score of 3.2 (based on the numerical scale described in McCartney et al., 1994, where 0 is a wild type embryo and 6 indicates the most severe defects).
Severe hypomorph. Homozygous embryos derived from homozygous females show an expansion of naked cuticle at the expense of denticles.
Apc233, ApcQ8, AxnS044230 has neuroanatomy defective | somatic clone | third instar larval stage phenotype
|Phenotype Manifest In|
Apc233/Apc233 is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4elav-C155, armScer\UAS.Exel
No apical constriction is seen in the cells surrounding the wing pouch in Apc[Q8] Apc2 double mutant third instar larval clones. Apc2[19-3] Apc[Q8] double mutant clone cells generated in the medullar region of third instar larval brains sometimes segregate from their neighbours to form cysts. When clones are induced in the medullar neurons the axons extend correctly to the medullar neuropil.
Apc2 Apc[Q8] double mutant intestinal stem cell clones in the adult midgut show hyperplasia. The hyperplasia seen in Apc2 Apc[Q8] double mutant intestinal stem cell clones in the adult midgut is completely suppressed if they are also expressing pan[ΔN.Scer\UAS] under the control of Scer\GAL4[tub].
The photoreceptor apoptosis phenotype seen in flies expressing armScer\UAS.Exel under the control of Scer\GAL4elav-C155 is partially suppressed by Apc233/Apc233. ApcQ8 Apc25-3/ApcQ8 Apc233 double mutants show expansion of sternal territory in the abdomen and ectopic sternal bristles, at the expense of the pleura. ApcQ8 Apc2G5028/ApcQ8 Apc233 double mutants show expansion of sternal territory in the abdomen and ectopic sternal bristles, at the expense of the pleura.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 5 )|