FB2025_01 , released February 20, 2025
Allele: Dmel\HDAC6UAS.Tag:V5
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General Information
Symbol
Dmel\HDAC6UAS.Tag:V5
Species
D. melanogaster
Name
FlyBase ID
FBal0215187
Feature type
allele
Associated gene
Dmel\HDAC6
Associated Insertion(s)
Carried in Construct
P{UAS-HDAC6.V5}
Also Known As
UAS-hdac6, UAS-dHDAC6
Key Links
Transgenic product class
wild_type
(Pandey et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Pandey et al., 2007)
Mutagen
in vitro construct
(Pandey et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-HDAC6.V5}
Cytology
Description

UAS regulatory sequences drive expression of wild-type HDAC6 tagged with Tag:V5.

(Pandey et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
HDAC6
Tagged with
Tag:V5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Kennedy's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(nec)
      (Pandey et al., 2007)
      modeled by Hsap\ARQ52.UAS
      (Pandey et al., 2007)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of HDAC6Scer\UAS.T:SV5\V5 under the control of Scer\GAL4Act.PU results in synaptic T-bars with larger 'top sizes' compared to controls, enabling them to contact more synaptic vesicles. The excitatory junctional current amplitude is significantly increased upon HDAC6Scer\UAS.T:SV5\V5 overexpression (under the control of Scer\GAL4nSyb.PU. Given that the mean miniature EJC amplitude is not significantly affected, the quantal content upon overexpression of HDAC6Scer\UAS.T:SV5\V5 is increased.

      (Miskiewicz et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      HDAC6UAS.Tag:V5, Scer\GAL4GMR.PF is a suppressor of eye phenotype of Hsap\APPAβ42.UAS.Tag:SS(nec), Scer\GAL4GMR.PF

      (Pandey et al., 2007)

      HDAC6UAS.Tag:V5, Scer\GAL4GMR.PF is a suppressor of eye | heat sensitive phenotype of Prosβ21.UAS, Scer\GAL4GMR.PF

      (Pandey et al., 2007)

      HDAC6UAS.Tag:V5, Scer\GAL4GMR.PF is a suppressor of eye | drug conditional phenotype of Hsap\ARQ52.UAS, Scer\GAL4GMR.PF

      (Pandey et al., 2007)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of HDAC6Scer\UAS.T:SV5\V5 under the control of Scer\GAL4ey-OK107 fails to suppress the axon degeneration seen in bskflp147E mutant mushroom body neuron clones.

      (Rallis et al., 2013)

      The retinal degeneration seen in flies expressing Prosβ21.Scer\UAS under the control of Scer\GAL4GMR.PF at 28oC is suppressed by co-expression of HDAC6Scer\UAS.T:SV5\V5.

      The ability of HDAC6Scer\UAS.T:SV5\V5 to suppress the rough eye phenotype seen in flies expressing Prosβ21.Scer\UAS under the control of Scer\GAL4GMR.PF at 28oC is suppressed by co-expression of Atg12dsRNA.Scer\UAS.

      (Pandey et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of HDAC6Scer\UAS.T:SV5\V5 partially suppresses the rough eye phenotype of flies expressing Hsap\APPAβ42.Scer\UAS.T:SS-nec under the control of Scer\GAL4GMR.PF.

      (Pandey et al., 2007)

      The rough eye phenotype seen in flies expressing Hsap\ARQ52.Scer\UAS under the control of Scer\GAL4GMR.PF in the presence of dihydrotestosterone (DHT) is suppressed by co-expression of HDAC6Scer\UAS.T:SV5\V5.

      The ability of HDAC6Scer\UAS.T:SV5\V5 to suppress the rough eye phenotype seen in flies expressing Hsap\ARQ52.Scer\UAS under the control of Scer\GAL4GMR.PF in the presence of dihydrotestosterone (DHT) is suppressed by co-expression of Atg12dsRNA.Scer\UAS.

      (Pandey et al., 2007)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HDAC6Scer\UAS.T:SV5\V5
      HDAC6UAS.Tag:V5
      Name Synonyms
      Secondary FlyBase IDs
        References (7)