Allele Dmel\tow⁷⁵⁴

General Information
Symbol	Dmel\tow⁷⁵⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0215227
Feature type	allele	Associated gene	Dmel\tow

Allele class
Mutagen	Delta2-3
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	Delta2-3 (Chung et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{lacW}tow⁴⁹³⁸ (Chung et al., 2007)
Nature of the lesion	Statement Reference Imprecise excision of the P{lacW}tow⁴⁹³⁸ insertion, resulting in a 7.4kb deletion that removes the entire tow open reading frame (the first noncoding exon and part of the first intron remain) and part of the neighbouring CG10077 gene (sequences encoding 160 amino acids of the 3' end of CG10077-RA are removed). (Chung et al., 2007)
Caused by aberration	Df(3L)tow⁷⁵⁴ (Chung et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Chung et al., 2007)
Phenotype Manifest In

Detailed Description
	Statement Reference The wing phenotypes caused by expression of tow[A1.Scer\UAS] under the control of Scer\GAL4[arm.PS] are relieved in a tow[754] homozygous background. Homozygotes show a weak increase in the intervein area between wing veins 3 and 4 compared to wild type. The number of campaniform sensilla along wing vein 3 is normal. (Ayers et al., 2009) Mutant flies show no eye polarity defects. (Chung et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference tow[+]/tow⁷⁵⁴ is an enhancer of visible \| dominant phenotype of stan^VC31 (Chung et al., 2007)
Suppressor of
Statement Reference tow[+]/tow⁷⁵⁴ is a suppressor \| partially of planar polarity defective phenotype of Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa (Chung et al., 2007)
Other
Statement Reference sha^VB13, tow[+]/tow⁷⁵⁴ has visible phenotype (Chung et al., 2007)
Phenotype Manifest In
Enhancer of
Statement Reference tow[+]/tow⁷⁵⁴ is an enhancer of wing hair \| supernumerary phenotype of stan^VC31 (Chung et al., 2007) tow⁷⁵⁴/tow⁷⁵⁴ is an enhancer of sensillum campaniformium of dorsal radius phenotype of ptc^Conf-1 (Ayers et al., 2009, Ayers et al., 2009)
Suppressor of
Statement Reference tow[+]/tow⁷⁵⁴ is a suppressor \| partially of ommatidium phenotype of Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa (Chung et al., 2007)
Other
Statement Reference ptc¹⁶/ptc[+], tow⁷⁵⁴ has 1st posterior cell phenotype (Ayers et al., 2009) ptc¹⁶/ptc[+], tow⁷⁵⁴ has sensillum campaniformium of dorsal radius phenotype (Ayers et al., 2009) sha^VB13, tow[+]/tow⁷⁵⁴ has wing hair \| supernumerary phenotype (Chung et al., 2007) sha^VB13, tow[+]/tow⁷⁵⁴ has wing hair phenotype (Chung et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference ptc[16]/+ ; tow[754]/tow[754] flies show a slight increase in the mean number of The number of campaniform sensilla (CS) along wing vein 3 compared to wild type, and the percentage of wings with aberrant CS numbers is also increased. The intervein area between veins 3 and 4 is also increased. (Ayers et al., 2009) The planar polarity defects seen in the eyes of animals expressing fz^Scer\UAS.cAa under the control of Scer\GAL4^hs.2sev are almost completely suppressed by tow⁷⁵⁴/+ (79.7% of ommatidia are correctly rotated). The multiple wing hair phenotype seen in dsh¹/Y flies is suppressed by tow⁷⁵⁴/+, but the defects in polarity of the hairs is not affected. The number of multiple wing hairs seen in stan^VC31/+ flies is enhanced if they are also carrying tow⁷⁵⁴/+. tow⁷⁵⁴/+ increases the number of small and multiple wing hairs seen in a sha^VB13/sha^VB13 background. (Chung et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	tow⁷⁵⁴ (Ayers et al., 2009, Chung et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Ayers et al., 2009, Dev. Biol. 329(2): 280--293 Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila. [FBrf0208057] Chung et al., 2007, Genetics 176(2): 891--903 The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. [FBrf0202398]

Allele Dmel\tow754

Allele Dmel\tow⁷⁵⁴