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General Information
Symbol
Dmel\ttm50IE1
Species
D. melanogaster
Name
FlyBase ID
FBal0215234
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G2731331A

Reported nucleotide change:

G?A

Amino acid change:

W197term | ttm50-PA; W197term | ttm50-PB

Reported amino acid change:

W197term

Comment:

TGG to TAG nonsense mutation in codon Trp197.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A.

Amino acid replacement: W197term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous larvae are much smaller than control larvae of the same age and the larvae die as first instar larvae after surviving for approximately 1 week.

Homozygous clones in the wing contain only one of two cells in contrast to the large control twin spots. Homozygous germline clones cannot be obtained.

When homozygous clones are induced in polyploid cells in the larval salivary glands, the network of mitochondria in these cells appears less developed than in wild type and there is weakened Mitotracker Red staining, indicating a reduction in mitochondrial activity.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)