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General Information
Symbol
Dmel\ttm50UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0215237
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of ttm50 tagged at the C-terminal end with a triple Tag:HA tag.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ttm50Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4109(2)80 results in fragmented spherical mitochondrial morphology as well as shortening of the dendritic arbor in the class IV ddaC neurons in third instar larvae. ttm50Scer\UAS.T:Ivir\HA1 expression driven by either Scer\GAL4221 or Scer\GAL4smid-C161 also leads to moderate dendrite loss.

Expression of ttm50Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act5C can result in lethality, depending on the P{UAS-ttm50.HA} insertion line used.

Expression of ttm50Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF results in a mild rough eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The shortening of the dendritic arbor in class IV ddaC neurons observed in third instar larvae expressing ttm50Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4109(2)80 can be rescued by co-expression of PPP1R15Scer\UAS.cMa.

The rough eye phenotype caused by expression of ttm50Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF is suppressed by Df(3L)H99/+ or Wunspecified/+ and enhanced by thunspecified/+.

Xenogenetic Interactions
Statement
Reference

Co-expression of BacA\p35Scer\UAS.cHa almost completely suppresses the rough eye phenotype caused by expression of ttm50Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF, and in addition, the total number of ommatidia is increased in these flies.

Co-expression of BacA\p35Scer\UAS.cHa and ttm50Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4en-e16E results in an increase in nuclear density and an increase in cell proliferation (as assayed by BrdU incorporation) in the imaginal disc.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ttm50Scer\UAS.T:Ivir\HA1
ttm50UAS.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (2)