FB2025_01 , released February 20, 2025
Allele: Dmel\unc-104O3.1
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General Information
Symbol
Dmel\unc-104O3.1
Species
D. melanogaster
Name
FlyBase ID
FBal0215326
Feature type
allele
Associated gene
Dmel\unc-104
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Barkus et al., 2008)
Mutagen
ethyl methanesulfonate
(Barkus et al., 2008)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  nervous system disease
      CEA with unc-104bris
      (Li et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      unc-104O3.1/unc-104P350 larvae are sluggish and show uncoordinated crawling movements, consistent with neuronal defects. However, they show no signs of dystonic posterior paralysis.

      The distribution and movement of neuropeptide vesicles is affected in unc-104O3.1/unc-104P350 larval motorneurons. The anterograde axonal flux and net velocity of dense-core vesicles is reduced relative to wild-type. Anterograde dense-core vesicles have slower forward run velocities and shorter run lengths than in wild type. Retrograde dense-core vesicle run parameters are also reduced. The anterograde flux of synaptic vesicles and mitochondria is reduced but the mean net velocity is not significantly affected.

      (Barkus et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      unc-104P350/unc-104O3.1 is partially rescued by Scer\GAL4Toll-6-D42/unc-104UAS.RVB.GFP(S65T)

      (Barkus et al., 2008)
      Comments

      Expression of unc-104Scer\UAS.RVB.T:Avic\GFP-S65T in motorneurons, under the control of Scer\GAL4D42, partially rescues the lethality of unc-104O3.1/unc-104P350 mutants. The rescued animals sometimes die at pharate adult stages and mature adults are behaviorally depressed.

      (Barkus et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      O3.1
      (Barkus et al., 2008)
      unc-104O3.1
      (Li et al., 2017, Barkus et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)