FlyBase Allele Report: Dmel\Rab6[T26N.UAS.YFP]

General Information

Symbol

Dmel\Rab6^T26N.UAS.YFP

Species

D. melanogaster

Name

FlyBase ID

FBal0215396

Feature type

allele

Associated gene

Dmel\Rab6

Associated Insertion(s)

Carried in Construct

P{UAST-YFP.Rab6.T26N}

Also Known As

DN-Rab6

Key Links

Transgenic product class

dominant_negative_variant

(Zhang et al., 2007)

missense_variant

(Zhang et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(Zhang et al., 2007)

missense_variant

(Zhang et al., 2007)

Mutagen

in vitro construct

(Zhang et al., 2007, Zhang et al., 2007)

Progenitor genotype

Carried in construct

P{UAST-YFP.Rab6.T26N}

Cytology

Description

Amino acid replacement: T26N.

(Zhang et al., 2007)

UASt regulatory sequences drive expression of a predicted dominant negative form of Rab6 that is tagged at the N-terminal end with YFP.

(Zhang et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Rab6

Tagged with

YFP

yellow fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The kinetics of maturation of phagosomes containing pHrodo-conjugated S. aureus by adult hemocytes expressing Rab6^{T26N.Scer\UAS.T:Avic\GFP-YFP} under the control of Scer\GAL4^Hml.Δ are not significantly different from those seen in control hemocytes.

(Garg and Wu, 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Rab6^T26N.UAS.YFP/Scer\GAL4^Act5C.PP is a non-enhancer of abnormal neuroanatomy | somatic clone phenotype of Rich¹

(Tong et al., 2011)

NOT Suppressor of

Statement

Reference

Rab6^T26N.UAS.YFP/Scer\GAL4^Act5C.PP is a non-suppressor of abnormal neuroanatomy | somatic clone phenotype of Rich¹

(Tong et al., 2011)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Rab6^T26N.UAS.YFP/Scer\GAL4^Act5C.PP is a non-enhancer of photoreceptor cell R7 | somatic clone phenotype of Rich¹

(Tong et al., 2011)

NOT Suppressor of

Statement

Reference

Rab6^T26N.UAS.YFP/Scer\GAL4^Act5C.PP is a non-suppressor of photoreceptor cell R7 | somatic clone phenotype of Rich¹

(Tong et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of Rab6^{T26N.Scer\UAS.T:Avic\GFP-YFP} in Rich¹ eye clones made using the 'MARCM' system neither suppresses nor enhances the R7 targeting defects caused by Rich¹.

(Tong et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

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