Allele Dmel\Rab6^{Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP}

General Information
Symbol	Dmel\Rab6^{Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0215397
Feature type	allele	Associated gene	Dmel\Rab6

Allele class
Mutagen	in vitro construct - amino acid replacement, in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Zhang et al., 2007, Zhang et al., 2007) in vitro construct - coding region fusion (Zhang et al., 2007) in vitro construct - regulatory fusion (Zhang et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q71L. (Zhang et al., 2007) Scer\UAS regulatory and P\T promoter sequences drive expression of a predicted constitutively active form of Rab6 which is tagged at the N-terminal end with T:Avic\GFP^YFP. (Zhang et al., 2007)
Carried in construct	P{UASp-YFP.Rab6.Q71L} (Zhang et al., 2007, Zhang et al., 2007, Uytterhoeven et al., 2011, Tong et al., 2011)
Tagged with	T:Avic\GFP^YFP (Zhang et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Rab6^{Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP}/Scer\GAL4^Act5C.PP is a suppressor of neuroanatomy defective \| somatic clone phenotype of Rich¹ (Tong et al., 2011)
Phenotype Manifest In
Suppressor of
Statement Reference Rab6^{Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP}/Scer\GAL4^Act5C.PP is a suppressor of photoreceptor cell R7 \| somatic clone phenotype of Rich¹ (Tong et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Overexpression of Rab6[Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP] in Rich[1] eye clones made using the 'MARCM' system greatly suppresses the R7 targeting defects caused by Rich[1]. (Tong et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	9777 y¹ P{UASp-YFP.Rab6.Q71L}23 w^* 9776 y¹ w^*; P{UASp-YFP.Rab6.Q71L}05
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Rab6^{Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP}
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Chan et al., 2011, Curr. Biol. 21(20): 1704--1715 Systematic discovery of rab GTPases with synaptic functions in Drosophila. [FBrf0216517] Tong et al., 2011, Neuron 71(3): 447--459 Rich Regulates Target Specificity of Photoreceptor Cells and N-Cadherin Trafficking in the Drosophila Visual System via Rab6. [FBrf0214681] Uytterhoeven et al., 2011, Cell 145(1): 117--132 Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins. [FBrf0213384] Zhang et al., 2007, Genetics 176(2): 1307--1322 Thirty-one flavors of Drosophila Rab proteins. [FBrf0201049]
Supplementary material	Zhang et al., 2007, Genetics 176(2): Supplement to Zhang et al., 2007. [FBrf0203184]

Allele Dmel\Rab6Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP

Allele Dmel\Rab6^{Q71L.Scer\UAS.P\T.T:Avic\GFP-YFP}