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General Information
Symbol
Dmel\Rab11Q70L.UASp.YFP
Species
D. melanogaster
Name
FlyBase ID
FBal0215412
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-YFP-Rab11CA
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q70L.

UASp regulatory sequences drive expression of a predicted constitutively active form of Rab11 that is tagged at the N-terminal end with YFP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Rab11Q70L.Scer\UAS.P\T.T:Avic\GFP-YFP in the posterior compartment of the wing via Scer\GAL4en-e16E at 29[o]C results in multiple trichomes.

Expression of Rab11Q70L.Scer\UAS.P\T.T:Avic\GFP-YFP under the control of Scer\GAL4ninaE.PT does not result in light-dependent retinal degeneration (flies raised under 12 hour light/12 our dark conditions show a normal electroretinogram amplitude at 3 weeks of age).

Bristle morphogenesis is not affected by expression of Rab11Q70L.Scer\UAS.P\T.T:Avic\GFP-YFP under the control of Scer\GAL4sca.PU.

Expression via Scer\GAL4pnr-MD237 results in flies with a wild type notum, apart from a single fly with cleft thorax.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Enhanced by
Enhancer of
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

gishe01759 dominantly enhances the wing hair phenotype resulting from the expression of Rab11Q70L.Scer\UAS.P\T.T:Avic\GFP-YFP via Scer\GAL4en-e16E.

Co-expression of Rab11Q70L.Scer\UAS.P\T.T:Avic\GFP-YFP and gishGD10588 via Scer\GAL4en-e16E results in a strong enhancement of the wing hair phenotype compared with that resulting from the expression of either transgene alone.

Co-expression of Rab11Q70L.Scer\UAS.P\T.T:Avic\GFP-YFP weakly suppresses the uninflated wing phenotype of Scer\GAL4Ccap.PP, OsbpScer\UAS.cMa flies.

The reduction in amplitude and in the size of the "on" and "off" transients of the electroretinogram that is seen in 3 week old flies containing homozygous CragC clones in the eye when they are raised under 12 hour light/12 hour dark conditions is partially suppressed by expression of Rab11Q70L.Scer\UAS.P\T.T:Avic\GFP-YFP under the control of Scer\GAL4ey.PH. Rhabdomere morphology is also better preserved in these animals compared to flies containing homozygous CragC clones in the eye in an otherwise wild-type background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Rab11Q70L.Scer\UAS.P\T.T:Avic\GFP-YFP
Rab11Q70L.UASp.YFP
Rab11[Q70L]
Name Synonyms
Secondary FlyBase IDs
    References (14)